5545960
Tocris Bioscience™ PF 5274857 hydrochloride
High affinity and selective Smoothened (Smo) receptor antagonist
Manufacturer: Fischer Scientific
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Purity
>98%
Product Type
PF 5274857 hydrochloride
Molecular Weight (g/mol)
473.42
Inhibitors
PF 5274857 hydrochloride
Related Products
Description
- High affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM)
- Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes
- Inhibits Shh-induced Hedgehog signaling in MEF cells
- Induces tumor regression in a medulloblastoma allograft mouse model
- Orally available and brain penetrant.
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Purity: >98%
Product Type: PF 5274857 hydrochloride
Molecular Weight (g/mol): 473.42
Inhibitors: PF 5274857 hydrochloride
Purity:
>98%
Product Type:
PF 5274857 hydrochloride
Molecular Weight (g/mol):
473.42
Inhibitors:
PF 5274857 hydrochloride
Purity: >98%
Product Type: Phortress
Molecular Weight (g/mol): 459.41
Inhibitors: Phortress
Purity:
>98%
Product Type:
Phortress
Molecular Weight (g/mol):
459.41
Inhibitors:
Phortress
Purity: >98%
Product Type: PHT 427
Molecular Weight (g/mol): 409.61
Inhibitors: PHT 427
Purity:
>98%
Product Type:
PHT 427
Molecular Weight (g/mol):
409.61
Inhibitors:
PHT 427
Purity: >98%
Product Type: PPQ 102
Molecular Weight (g/mol): 438.48
Inhibitors: PPQ 102
Purity:
>98%
Product Type:
PPQ 102
Molecular Weight (g/mol):
438.48
Inhibitors:
PPQ 102