5545978
Tocris Bioscience™ PRT 4165
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Purity
>99%
Product Type
PRT 4165
Molecular Weight (g/mol)
235.24
Inhibitors
PRT 4165
Related Products
Description
- PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1); inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit
- Prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α)
- Also shown to inhibit the in vitro E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex, inhibiting H2A/H2AX ubiquitination
- Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro .
Compare Similar Items
Show Difference
Purity: >99%
Product Type: PRT 4165
Molecular Weight (g/mol): 235.24
Inhibitors: PRT 4165
Purity:
>99%
Product Type:
PRT 4165
Molecular Weight (g/mol):
235.24
Inhibitors:
PRT 4165
Purity: >98%
Product Type: PS 1145 dihydrochloride
Molecular Weight (g/mol): 395.67
Inhibitors: PS 1145 dihydrochloride
Purity:
>98%
Product Type:
PS 1145 dihydrochloride
Molecular Weight (g/mol):
395.67
Inhibitors:
PS 1145 dihydrochloride
Purity: __
Product Type: Pyridostatin pentahydrochloride
Molecular Weight (g/mol): __
Inhibitors: Pyridostatin pentahydrochloride
Purity:
__
Product Type:
Pyridostatin pentahydrochloride
Molecular Weight (g/mol):
__
Inhibitors:
Pyridostatin pentahydrochloride
Purity: 0.95
Product Type: Reversan
Molecular Weight (g/mol): 441.52
Inhibitors: Reversan
Purity:
0.95
Product Type:
Reversan
Molecular Weight (g/mol):
441.52
Inhibitors:
Reversan