5546053

Tocris Bioscience™ TAK 165

Potent and selective ErbB2 inhibitor

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>99%

Product Type

TAK 165

Inhibitors

TAK 165

Gene Alias

Mubritinib

Molecular Weight (g/mol)

468.47

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Description

  • Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src
  • Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo .

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Molecular Weight (g/mol):
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