5545989

Tocris Bioscience™ Reversan

Selective MRP1 and P-gp inhibitor

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

0.95

Product Type

Reversan

Inhibitors

Reversan

Content And Storage

Store at -20°C

Molecular Weight (g/mol)

441.52

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Description

  • Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp)
  • Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat
  • No
  • 2252), vincristine (Cat
  • No
  • 1257) and etoposide (Cat
  • No
  • 1226) by 3.8-, 14.6- and 11.6-fold respectively
  • Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo
  • Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.

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