5545704

Tocris Bioscience™ BAG 956

Dual PI 3-kinase and PDPK1 (PDK1) inhibitor

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

98%

Product Type

BAG 956

Inhibitors

BAG 956

Content And Storage

Store at -20°C

Molecular Weight (g/mol)

427.5

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Description

  • Dual PDPK1 (PDK1) and class I PI 3-K inhibitor (IC50 values are 245, 56, 446, 35 and 117 nM for PDPK1 and PI 3-K p110 -α, -β, -δ, and -γ respectively)
  • Inhibits cellular AKT phosphorylation at Thr308
  • Blocks cell proliferation, causing arrest in G1 phase of the cell cycle
  • Slows tumor progression in mouse xenograft models.

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