5546079

Tocris Bioscience™ Tolvaptan

Potent and selective vasopressin V2 receptor antagonist; renoprotective and orally active

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>98%

Product Type

Tolvaptan

Inhibitors

Tolvaptan

Gene Alias

OPC-41061

Molecular Weight (g/mol)

448.94

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Description

  • Potent and selective competitive vasopressin V2 receptor antagonist (Ki values are 0.06 and 12.3 nM for V2 and V1a receptors respectively)
  • Decreases urine osmolality and increases serum sodium concentrations
  • Delays the onset of end-stage renal disease in a mouse model of polycystic kidney disease
  • Exhibits myocardial and renal protective effects in hypertensive heart failure rats
  • Orally active.

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