Host Species:
Human, Mouse, Rat, Bovine, Xenopus, Yeast, Zebrafish
For Use With (Application):
Inhibition of MyD88 dependent TLR/IL-1R signaling activitiy by interefering with MyD88 homodimer formation. Inhibitory peptide at 100 uM concentration may be a starting point. However, useful concentration of peptide may vary depending on experimental condition and cell type. Incubate cells for 24 hr with peptides before stimulating with ligands. Use in Functional inhibition reported in multiple pieces of scientific literature Use in In vivo assay reported in scientific literature (PMID 24755282) Use in blocking neutralizing reported in scientific literature (PMID 24886588) Use in In vitro assay reported in scientific literature (PMID 25810567) Use in ELISA reported in scientific literature (PMID 23469306). Use in FLOW cytometry reported in scientific literature (PMID 27870876) . Use in Binding inhibition reported in scientific literature (PMID 28302163). Use in Immunohistochemistry reported in scientific literature (PMID 28282921).
Molecular Weight (g/mol):
3100
Components:
2 x 1mg: MyD88 Homodimerization Inhibitor peptide (lyophilized) DRQIKIWFQNRRMKWKKRDVLPGT (MyD88 homodimerization sequence: RDVLPGT). Molecular weight: 31002 x 1mg: Antennapedia Control peptide (lyophilized) DRQIKIWFQNRRMKWKK. Molecular weight: 23615mg size will contain 5mg of each peptide (MyD88 Homodimerization Inhibitor peptide and Antennapedia Control peptide)
Content And Storage:
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Product Type:
MyD88 Inhibitor Peptide Set