Poly(ethylene glycol) linear dendrimer

Description

• General description: Polymer architecture: Dendron-functionalized PEGGeneration: 4PEG Average Mn: 6,000End group functionality: Boc-protected amineNo. surface groups: 32Calculated mol. wt.: 14970.98 g/molBoc: tert-ButyloxycarbonylBis-MPA: 2,2-bis(hydroxymethyl)propionic acid
• Application: Bis-MPA (or 2,2-bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. PEG-core dendrimers feature excellent solubility in water and a high degree of functionality per PEG chain, making them strong candidates for advanced drug delivery systems or as targeting vessels. Additionally, the terminal amine groups can readily be used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds, to yield highly functionalized materials for a variety of biomedical applications.