TissueFab® - low endotoxin GelMA-UV bioink

Description

• General description: Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation. Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.
• Application: Gelatin methacrylate based bioinks have been used in the following bioprinting applications: osteogenic[1],chondrogenic [2][3], hepatic [4][5][6], adipogenic [7], vasculogenic [8], epithelial [6], endothelial [9][10], cardiac valve [11],skin [12], tumors [10]
• Features and Benefits: Ready-to-use formulation optimized for high printing fidelity and cell viability, eliminating the lengthy bioink formulation development processStep-by-step protocols developed and tested by MilliporeSigma 3D Bioprinting Scientists, no prior 3D bioprinting experience needeSuitable for different extrusion-based 3D bioprinter modelMethacrylamide functional group can also be used to control the hydrogel physical parameters such as pore size, degradation rate, and swell ratio.
• Legal Information: TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany