TissueFab® bioink Alg(Gel)ma -UV/365 nm

Description

• General description: Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell-binding motifs, gelatin has become a highly sought material for tissue engineering applications. Alginate is a naturally occurring polymer widely applied for bioprinting applications as its printability can be easily modified by altering the polymer density and crosslinking with the addition of calcium chloride (CaCl2). Alginate is often combined with gelatin to facilitate cell adhesion and differentiation. Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.
• Application: Gelatin methacrylate based bioinks have been used in the following bioprinting applications: osteogenic [1],chondrogenic [2][3], hepatic [4][5][6], adipogenic [7], vasculogenic [8] , epithelial [6], endothelial [9], cardiac valve [10],skin [11], tumors [9]
• Features and Benefits: Ready-to-use formulation optimized for high printing fidelity and cell viability, eliminating the lengthy bioink formulation development processStep-by-step protocols developed and tested by MilliporeSigma 3D Bioprinting Scientists, no prior 3D bioprinting experience neededSuitable for different extrusion-based 3D bioprinter modelMethacrylamide functional group can also be used to control the hydrogel physical parameters such as pore size, degradation rate, and swell ratio.
• Legal Information: TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany