Hyaluronic acid hydrazide

Description

• General description: Hyaluronic acid hydrazide is a versatile and innovative functionalized natural polymer whereby the carboxylic acid moieties of hyaluronic acid are modified with mono- and polyfunctional hydrazides via controlled synthesis. Hyaluronic acid (HA), linear polysaccharide composed of alternating 1,4-linked units of 1,3-linnked glucuronic acid and N-acetylglucosamine, is a crucial component of the extracellular matrix (ECM). The hydrazide groups are highly reactive with aldehydes, leading to the formation of acyl hydrazone linkages. This is particularly useful for linking glycoproteins or carbohydrates in a site specific manner.
• Application: Hyaluronic acid hydrazide can be used for a wide range of applications. By harnessing the controlled hydrazide modification of hyaluronic acid, this product can be used to create tailored solutions for various fields, including biomedical research, pharmaceuticals, and tissue engineering. Applications include: Developing new drug delivery systems such as prodrugs Studying cell motility in 3D cell culture scaffolds Engineering biocompatible scaffolds and hydrogels for areas such as cartilage tissue engineering The hyaluronic acid hydrazide can also be used as an intermediate to synthesize other HA derivatives with various functional groups.
• Features and Benefits: Biocompatible and biodegradable Greater than 60% functionalized Tailorable for tethering additional functional groups or biochemical moieties