200006992
Tocris Bioscience™ MK 2206 dihydrochloride
Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1032350-13-2
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Chemical Name or Material
8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride
Target
Akt (Protein Kinase B) Inhibitors
Purity
0.98
CAS
1032350-13-2
Molecular Formula
C25H21N5O.2HCl
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ MK 2206 dihydrochloride | Fischer Scientific | ₹ 11,901.40 | |
| | Tocris Bioscience™ MK 2206 dihydrochloride | Fischer Scientific | ₹ 50,052.60 | |
 | Medchemexpress LLC HY-10358 200mg , MK-2206 (dihydrochloride) CAS:1032350-13-2 Purity:>98% | Medchemexpress LLC | ₹ 40,427.10 | |
 | Apexbio Technology LLC MK-2206 dihydrochloride, 500mg. Cas: 1032350-13-2 MFCD: MFCD14584463. Akt1/2/3 inhibitor | Apexbio Technology LLC | ₹ 1,28,340.00 | |
| | Medchemexpress LLC 10 mM * 1 mL in DMSO, MK2206 | 1032350-13-2 | Medchemexpress LLC | ₹ 5,929.31 | |
 | Selleck Chemical LLC MK-2206 2HCl 5mg 1032350-13-2 | Selleck Chemical LLC | ₹ 15,092.78 | |
 | Selleck Chemical LLC MK-2206 2HCl 25mg 1032350-13-2 | Selleck Chemical LLC | ₹ 40,760.78 | |
 | AdipoGen MK-2206 dihydrochloride, 1032350-13-2, MFCD14584463, 1 mg | AdipoGen | ₹ 7,477.94 | |
 | Cayman Chemical MK-2206 (hydrochloride), 1032350-13-2, 10 mg | Cayman Chemical | ₹ 10,429.76 | |
| | Cayman Chemical MK-2206 (hydrochloride), 1032350-13-2, 1 mg | Cayman Chemical | ₹ 4,483.34 |
Related Products
Description
- MK 2206 dihydrochloride is a potent and selective allosteric Akt inhibitor (IC50 values are 5 nM, 12 nM, and 65 nM for Akt1, Akt2, and Akt3, respectively)
- MK 2206 requires the Pleckstrin homology domain for its activity, and exhibits no inhibitory activity in a panel of 250 tested protein kinases
- MK 2206 induces growth inhibition of different cancer cell lines (IC50 in the range 3.4 and 28.6 μmol/L) and enhances antitumor efficacy of a range of standard chemotherapeutics
- It synergistically inhibits cell proliferation of human lung and breast cancer cells in combination with Erlotinib (Cat
- No
- 7194) by suppressing both the Ras/Erk and PI 3-K pathways in vitro and in vivo
- MK 2206 can be used to block the IL-22 - Akt signaling pathway for studying paneth cell differentiation.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride
Target: Akt (Protein Kinase B) Inhibitors
Purity: 0.98
CAS: 1032350-13-2
Molecular Formula: C25H21N5O.2HCl
Chemical Name or Material:
8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride
Target:
Akt (Protein Kinase B) Inhibitors
Purity:
0.98
CAS:
1032350-13-2
Molecular Formula:
C25H21N5O.2HCl
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