200007271
Tocris Bioscience™ TH 1760
Potent and selective NUDT15 hydrolase inhibitor
Manufacturer: Fischer Scientific
CAS Number: 2567914-01-4
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Chemical Name or Material
6-[[4-(1 H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3 H)-benzoxazolone
Target
Hydrolase Inhibitors
Purity
0.95
CAS
2567914-01-4
Molecular Formula
C20H18N4O5S
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ TH 1760 | Fischer Scientific | ₹ 74,162.81 | |
| | Tocris Bioscience™ TH 1760 | Fischer Scientific | ₹ 17,716.34 |
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Description
- TH 1760 is a potent and selective NUDT15 (nudix hydrolase 15) inhibitor (IC50 = 29 nM)
- Displays selectivity for NUDT15 when assayed at 100 μM against other Nudix enzymes (MTH1, NUDT2, 5, 9, 12, 14, 18, 22) and pyrophosphatases or at 10 μM when assayed with a Eurofins Cerep Safety Screen44 panel
- In vitro , TH 1760 treatment sensitizes cancer cell lines (NB4 and HL-60) to thiopurine.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: 6-[[4-(1 H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3 H)-benzoxazolone
Target: Hydrolase Inhibitors
Purity: 0.95
CAS: 2567914-01-4
Molecular Formula: C20H18N4O5S
Chemical Name or Material:
6-[[4-(1 H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3 H)-benzoxazolone
Target:
Hydrolase Inhibitors
Purity:
0.95
CAS:
2567914-01-4
Molecular Formula:
C20H18N4O5S
Chemical Name or Material: 3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1 H-pyrrolo[2,3-b]pyridine
Target: SNF1LK2/SIK2
Purity: 0.98
CAS: 1613710-01-2
Molecular Formula: C19H16N2O2S
Chemical Name or Material:
3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1 H-pyrrolo[2,3-b]pyridine
Target:
SNF1LK2/SIK2
Purity:
0.98
CAS:
1613710-01-2
Molecular Formula:
C19H16N2O2S
Chemical Name or Material: 2-[[[5-Bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]ethanol
Target: USP28
Purity: 0.98
CAS: 2165322-94-9
Molecular Formula: C17H16BrF4NO2
Chemical Name or Material:
2-[[[5-Bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]ethanol
Target:
USP28
Purity:
0.98
CAS:
2165322-94-9
Molecular Formula:
C17H16BrF4NO2
Chemical Name or Material: 4-[5,6-Dihydro-2-(2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline
Target: TGF-beta Receptor Inhibitors
Purity: 0.98
CAS: 700874-71-1
Molecular Formula: C26H27N5O2
Chemical Name or Material:
4-[5,6-Dihydro-2-(2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]quinoline
Target:
TGF-beta Receptor Inhibitors
Purity:
0.98
CAS:
700874-71-1
Molecular Formula:
C26H27N5O2