200007287
Tocris Bioscience™ RU.521
Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)
Manufacturer: Fischer Scientific
CAS Number: 2262452-06-0
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Chemical Name or Material
3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone
Target
Synthase/Synthetase Inhibitors
Purity
0.98
CAS
2262452-06-0
Molecular Formula
C19H12Cl2N4O3
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ RU.521 | Fischer Scientific | ₹ 21,432.78 | |
| | Tocris Bioscience™ RU.521 | Fischer Scientific | ₹ 89,581.32 | |
 | Medchemexpress LLC HY-114180 50mg , RU.521 CAS:2262452-06-0 Purity:>98% | Medchemexpress LLC | ₹ 44,020.62 |
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Description
- RU.521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor (Kd = 36.2 nM; IC50 values are 0.11 μM and 2.94 μM against m-cGAS and h-cGAS, respectively)
- RU.521 suppresses dsDNA-activated reporter activity but not 5'ppp-HP20 RNA or murine IFN-β-induced IFN-β1-dependent gene expression
- RU.521 reduces constitutive expression of type I interferon in primary macrophages from a mouse model of Aicardi-Gouti?res syndrome
- Pretreatment of chimeric antigen receptor (CAR) redirected T cells with RU.521 increases efficiency of virus-free gene editing by improving cell viability and CAR integration in cell line.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone
Target: Synthase/Synthetase Inhibitors
Purity: 0.98
CAS: 2262452-06-0
Molecular Formula: C19H12Cl2N4O3
Chemical Name or Material:
3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone
Target:
Synthase/Synthetase Inhibitors
Purity:
0.98
CAS:
2262452-06-0
Molecular Formula:
C19H12Cl2N4O3
Chemical Name or Material: 2-Ethyl-4,5,6,7-tetrahydro-N-[2-[(tetrahydro-2 H-pyran-2-yl)methoxy]phenyl]-2 H-indazole-3-carboxamide
Target: IP3R1
Purity: 0.98
CAS: 1214569-31-9
Molecular Formula: C22H29N3O3
Chemical Name or Material:
2-Ethyl-4,5,6,7-tetrahydro-N-[2-[(tetrahydro-2 H-pyran-2-yl)methoxy]phenyl]-2 H-indazole-3-carboxamide
Target:
IP3R1
Purity:
0.98
CAS:
1214569-31-9
Molecular Formula:
C22H29N3O3
Chemical Name or Material: 4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
Target: YAP1
Purity: 0.98
CAS: 1008768-41-9
Molecular Formula: C26H33N3O3
Chemical Name or Material:
4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
Target:
YAP1
Purity:
0.98
CAS:
1008768-41-9
Molecular Formula:
C26H33N3O3
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