200009250
Tocris Bioscience™ AMG 900
Potent pan-Aurora kinase inhibitor
Manufacturer: Fischer Scientific
CAS Number: 945595-80-2
The price for this product is unavailable. Please request a quote
Chemical Name or Material
N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine
Target
Aurora Kinase Inhibitors
Purity
98%
CAS
945595-80-2
Molecular Formula
C28H21N7OS
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ AMG 900 | -- | ₹ 17,043.50 | ||
Tocris Bioscience™ AMG 900 | -- | ₹ 71,867.50 | ||
eMolecules AMG-900 | 945595-80-2 | MFCD18633194 | 10mg | -- | ₹ 7,991.31 | ||
Selleck Chemical LLC AMG-900 5mg 945595-80-2 | -- | ₹ 18,156.00 | ||
945595-80-2 | AMG-900 | -- | ₹ 2,492.00 - ₹ 51,086.00 |
Related Products
Description
- AMG 900 is a potent pan-Aurora kinase inhibitor (IC50 values are 1 nM, 4 nM, and 5 nM for Aurora C, B, and A, respectively)
- It is more than 10-fold selective for Aurora kinases over JNK2, Tie2, p38α, Met, and TYK2
- AMG 900 inhibits autophosphorylation of Aurora A and B, as well as the phosphorylation of histone H3 on Ser in HeLa cells
- AMG 900 inhibits proliferation of 26 tumor cell lines (EC50 ranges from 0.7 nM - 5.3 nM), including Paclitaxel (Cat
- No
- 1097)-resistant tumor cell lines
- In an HCT116 tumor xenograft model, AMG 900 inhibits phosphorylation of histone H3 and tumor growth
- It is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C