Description

• KYT 0353 is a potent and selective inhibitor of L-type amino acid transporter 1 (LAT1) (IC50 = 60 nM for 14C-leucine uptake in H-29 cells)
• Also suppreses 14C-leucine uptake in renal proximal tubule cells expressing LAT1 (IC50 = 140 nM)
• Displays ∽500-fold selectivity for LAT1 over LAT2
• Reduces cell viability and induces apoptosis in YD-38 oral cancer cells
• Arrests growth in several tumor cell lines
• Exhibits growth inhibitory effects on HT-29 cells in vivo .