62-385
Tocris™ PKRA 7
Manufacturer: Tocris™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 62-385-Each-of-1 | In Stock | ₹ 20,336.50 |
62-385 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 20,336.50
GST (18%): ₹ 3,660.57
Total Price: ₹ 23,997.07
Chemical Name or Material
(3 R)-N-[(9-Chloro-3,4-dihydro-2 H-1,5-benzodioxepin-7-yl)methyl]-1-[(4-fluoro-3-methoxyphenyl)methyl]-N-(2-methylpropyl)-3-pyrrolidinecarboxamide hydrochloride
Target
Prokineticin R2/PROKR2
Purity
0.98
Quantity
5 mg
Molecular Formula
C27H34ClFN2O4.HCl
Related Products
Description
- PKRA 7 is a potent prokineticin (PK) receptor antagonist (IC50 values are 5.0 and 8.2 nM for PKR1 and PKR2, respectively)
- Reduces IL-1β and lL-6 expression in the joints and suppresses severity of arthritis in a mouse model of rheumatoid arthritis
- Inhibits PK2-induced expression of pro-migratory chemokines and chemokine receptors in macrophages
- Exhibits antitumor activity against glioblastoma and pancreatic cancer xenograft tumor models
- Also exhibits antiangiogenic activity in vivo
- Brain penetrant
- Cell-permeable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: (3 R)-N-[(9-Chloro-3,4-dihydro-2 H-1,5-benzodioxepin-7-yl)methyl]-1-[(4-fluoro-3-methoxyphenyl)methyl]-N-(2-methylpropyl)-3-pyrrolidinecarboxamide hydrochloride
Target: Prokineticin R2/PROKR2
Purity: 0.98
Quantity: 5 mg
Molecular Formula: C27H34ClFN2O4.HCl
Chemical Name or Material:
(3 R)-N-[(9-Chloro-3,4-dihydro-2 H-1,5-benzodioxepin-7-yl)methyl]-1-[(4-fluoro-3-methoxyphenyl)methyl]-N-(2-methylpropyl)-3-pyrrolidinecarboxamide hydrochloride
Target:
Prokineticin R2/PROKR2
Purity:
0.98
Quantity:
5 mg
Molecular Formula:
C27H34ClFN2O4.HCl
Chemical Name or Material: __
Target: __
Purity: __
Quantity: 25 μg
Molecular Formula: __
Chemical Name or Material:
__
Target:
__
Purity:
__
Quantity:
25 μg
Molecular Formula:
__
Chemical Name or Material: __
Target: __
Purity: __
Quantity: 100 μg
Molecular Formula: __
Chemical Name or Material:
__
Target:
__
Purity:
__
Quantity:
100 μg
Molecular Formula:
__
Chemical Name or Material: (3 AS,4 S,6 aR)-Hexahydro-N-[2-(4-hydroxyphenyl)ethyl]-2-oxo-1 H-thieno[3,4-d]imidazole-4-pentanamide
Target: Tyramide Signaling Amplification/TSA
Purity: 98%
Quantity: 25 mg
Molecular Formula: C18H25N3O3S
Chemical Name or Material:
(3 AS,4 S,6 aR)-Hexahydro-N-[2-(4-hydroxyphenyl)ethyl]-2-oxo-1 H-thieno[3,4-d]imidazole-4-pentanamide
Target:
Tyramide Signaling Amplification/TSA
Purity:
98%
Quantity:
25 mg
Molecular Formula:
C18H25N3O3S