61-805-RD

NMS 873

Manufacturer: Fischer Scientific

CAS Number: 1418013-75-8

Select a Size

Pack Size SKU Availability Price
Each of 1 61-805-RD-Each-of-1 In Stock ₹ 12,727.00

61-805-RD - Each of 1

₹ 12,727.00

In Stock

Quantity

1

Base Price: ₹ 12,727.00

GST (18%): ₹ 2,290.86

Total Price: ₹ 15,017.86

Chemical Name or Material

3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine

Assay Percent Range

>98%

Molecular Formula

C27H28N4O3S2

CAS

1418013-75-8

Quantity

5 mg

Formula Weight

Observed MW: 520.67

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Description

  • Potent p97 ATPase (VCP) allosteric inhibitor (IC50 = 30 nM)
  • Selective over all other AAA ATPases, HSP90 and kinases tested (IC50 >10 μM)
  • Activates the unfolded protein response (UPR) and modulates autophagosome maturation
  • Exhibits antiproliferative activity in cancer cells in vitro (IC50 values are 400 and 700 nM for HCT116 and HeLa cells respectively)
  • Reduces p97-sensitization to trypsin digestion.

SAFETY INFORMATION

  • Recommended Storage : Store at 4°C