7116107
NMS 873
Potent and selective p97 ATPase (VCP) allosteric inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1418013-75-8
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Chemical Name or Material
3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine
Assay Percent Range
>98%
Formula Weight
Observed MW: 520.67
CAS
1418013-75-8
Molecular Formula
C27H28N4O3S2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | NMS 873 | Fischer Scientific | ₹ 45,817.38 | |
| | NMS 873 | Fischer Scientific | ₹ 12,235.08 | |
 | eMolecules Medchem Express / NMS-873 / 5mg / 446266412 / HY-15713 / / 1418013-75-8 / MFCD28009371 / 520.670 / C27H28N4O3S2 | eMolecules | ₹ 9,824.00 | |
 | Apexbio Technology LLC allosteric and specific p97 inhibitor 1418013-75-8. MFCD28009371 | Apexbio Technology LLC | ₹ 5,818.08 | |
 | Sigma Aldrich Fine Chemicals Biosciences NMS-873 >=98% (HPLC) | 1418013-75-8 | MFCD28009371 | 25MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 61,687.05 | |
| | Sigma Aldrich Fine Chemicals Biosciences NMS-873 >=98% (HPLC) | 1418013-75-8 | MFCD28009371 | 5MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 16,875.00 |
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Description
- Potent p97 ATPase (VCP) allosteric inhibitor (IC50 = 30 nM)
- Selective over all other AAA ATPases, HSP90 and kinases tested (IC50 >10 μM)
- Activates the unfolded protein response (UPR) and modulates autophagosome maturation
- Exhibits antiproliferative activity in cancer cells in vitro (IC50 values are 400 and 700 nM for HCT116 and HeLa cells respectively)
- Reduces p97-sensitization to trypsin digestion.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C
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Show Difference
Chemical Name or Material: 3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine
Assay Percent Range: >98%
Formula Weight: Observed MW: 520.67
CAS: 1418013-75-8
Molecular Formula: C27H28N4O3S2
Chemical Name or Material:
3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine
Assay Percent Range:
>98%
Formula Weight:
Observed MW: 520.67
CAS:
1418013-75-8
Molecular Formula:
C27H28N4O3S2
Chemical Name or Material: α-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol
Assay Percent Range: >98%
Formula Weight: Observed MW: 254.29
CAS: 70132-50-2
Molecular Formula: C11H18N4O3
Chemical Name or Material:
α-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol
Assay Percent Range:
>98%
Formula Weight:
Observed MW: 254.29
CAS:
70132-50-2
Molecular Formula:
C11H18N4O3
Chemical Name or Material: (5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone
Assay Percent Range: >98%
Formula Weight: Observed MW: 293.4
CAS: 1558598-41-6
Molecular Formula: C14H15NO2S2
Chemical Name or Material:
(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone
Assay Percent Range:
>98%
Formula Weight:
Observed MW: 293.4
CAS:
1558598-41-6
Molecular Formula:
C14H15NO2S2
Chemical Name or Material: Rho GTPase Inhibitors
Assay Percent Range: >98%
Formula Weight: Observed MW: 430.55
CAS: 1380432-32-5
Molecular Formula: C25H30N6O
Chemical Name or Material:
Rho GTPase Inhibitors
Assay Percent Range:
>98%
Formula Weight:
Observed MW: 430.55
CAS:
1380432-32-5
Molecular Formula:
C25H30N6O