Tocris™ Pyridone 6

Description

• Pyridone 6 is a potent pan-JAK inhibitor; ATP-competitive inhibitor of JAK 1/2/3 and Tyk2 (IC50 values are 1, 5, 15 and 1 nM, respectively)
• Inhibits other kinases tested at 130 nM to >10 μM
• Inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks STAT5 phosphorylation
• Also inhibits Th1 and Th2 development, and promotes Th17 differentiation from naive T cells
• When used in combination with Retinoic acid, LY 294002 and CCG 1423, it induces intermediate mesoderm differentiation from ESCs
• Inhibits growth of primary myeloma cells grown in the presence of bone marrow stromal cells
• Cell-permeable.