68-295-0
Tocris™ (R)-Shikonin
Manufacturer: Tocris™
CAS Number: 517-89-5
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Chemical Name or Material
5,8-Dihydroxy-2-[(1 R)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione
Quantity
50 mg
Molecular Formula
C16H16O5
Product Type
Inhibitor
CAS
517-89-5
Target
Protein Tyrosine Phosphatase Inhibitors
Formula Weight
288.3
Purity
98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-N0822 10mg , Shikonin CAS:517-89-5 Purity:>98% | Medchemexpress LLC | ₹ 4,941.09 | |
 | MilliporeSigma™ Calbiochem™ Shikonin | MilliporeSigma™ | ₹ 12,279.57 | |
 | Medchemexpress LLC HY-N0822 100mg , Shikonin C.I. 75535;Isoarnebin 4 CAS:517-89-5 Purity:98% | Medchemexpress LLC | ₹ 24,705.45 | |
 | Enzo Life Sciences Shikonin (10mg). CAS: 517-89-5 | Enzo Life Sciences | ₹ 8,068.31 | |
 | Shikonin | Sigma Aldrich | ₹ 31,760.55 |
Related Products
Description
- (R)-Shikonin is a PTEN and inflammasome inhibitor
- Inhibits PTEN's phosphatase activity (IC50 = 2.7 μM) and NLRP3 activation
- Also blocks TNF-α and NF-κB signaling
- Attenuates HIV-1 replication at nanomolar concentrations
- (R)-Shikonin suppresses glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2 (PKM2) (IC50 = 0.3 μM) and inhibits tumor proliferation
- Induces necroptosis in MCF-7 and HEK293 cancer cell lines
- (R)-Shikonin also displays anti-inflammatory activity in a mouse model of collagen-induced arthritis.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: 5,8-Dihydroxy-2-[(1 R)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione
Quantity: 50 mg
Molecular Formula: C16H16O5
Product Type: Inhibitor
CAS: 517-89-5
Target: Protein Tyrosine Phosphatase Inhibitors
Formula Weight: 288.3
Purity: 98%
Chemical Name or Material:
5,8-Dihydroxy-2-[(1 R)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione
Quantity:
50 mg
Molecular Formula:
C16H16O5
Product Type:
Inhibitor
CAS:
517-89-5
Target:
Protein Tyrosine Phosphatase Inhibitors
Formula Weight:
288.3
Purity:
98%
Chemical Name or Material: N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride
Quantity: 10 mg
Molecular Formula: C32H26N4O2.HCl
Product Type: __
CAS: 168626-94-6
Target: __
Formula Weight: 535.04
Purity: 98%
Chemical Name or Material:
N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride
Quantity:
10 mg
Molecular Formula:
C32H26N4O2.HCl
Product Type:
__
CAS:
168626-94-6
Target:
__
Formula Weight:
535.04
Purity:
98%
Chemical Name or Material: N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride
Quantity: 50 mg
Molecular Formula: C32H26N4O2.HCl
Product Type: __
CAS: 168626-94-6
Target: __
Formula Weight: 535.04
Purity: 98%
Chemical Name or Material:
N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][benzazepin-6(1H)-yl)carbonyl]phenyl-[1,1'-biphenyl]-2-carboxamide hydrochloride
Quantity:
50 mg
Molecular Formula:
C32H26N4O2.HCl
Product Type:
__
CAS:
168626-94-6
Target:
__
Formula Weight:
535.04
Purity:
98%
Chemical Name or Material: (αS)-α-[cis-3-Hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-2-pyridinemethanol
Quantity: 5 mg
Molecular Formula: C17H17F3N2O2
Product Type: __
CAS: 1432051-63-2
Target: TRPV Antagonists
Formula Weight: 3434
Purity: 98%
Chemical Name or Material:
(αS)-α-[cis-3-Hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-2-pyridinemethanol
Quantity:
5 mg
Molecular Formula:
C17H17F3N2O2
Product Type:
__
CAS:
1432051-63-2
Target:
TRPV Antagonists
Formula Weight:
3434
Purity:
98%