71-605
Tocris™ DD 03-171
Manufacturer: Tocris™
CAS Number: 2366132-45-6
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 71-605-Each-of-1 | In Stock | ₹ 46,814.00 |
71-605 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,814.00
GST (18%): ₹ 8,426.52
Total Price: ₹ 55,240.52
Chemical Name or Material
4-(1,1-Dimethylethyl)-N-[3-[6-[[4-[[4-[6-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-4-yl]amino]acetyl]amino]hexyl]-1-piperazinyl]carbonyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]benzamide
Quantity
5 mg
Molecular Formula
C55H62N10O8
CAS
2366132-45-6
Target
Active Degraders
Purity
0.98
Related Products
Description
- DD 03-171 is a potent and selective BTK Degrader (PROTAC™) (IC50 = 5.1 nM); degrades BTK in a proteasome- and CRBN-dependent manner
- Suppresses BTK signaling and proliferation in mantle cell lymphoma (MCL) cells by degrading BTK, IKFZ1, and IKFZ3 (3 validated targets in B-cell malignancies)
- Also degrades Ibrutinib (Cat
- No
- 6813) -resistant C481S-BTK mutant cancer cells
- Exhibits no binding against a panel of 468 kinases at 1 μM
- Reduces tumor burden and extends survival in lymphoma patient-derived xenograft models
- PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 4-(1,1-Dimethylethyl)-N-[3-[6-[[4-[[4-[6-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-4-yl]amino]acetyl]amino]hexyl]-1-piperazinyl]carbonyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]benzamide
Quantity: 5 mg
Molecular Formula: C55H62N10O8
CAS: 2366132-45-6
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
4-(1,1-Dimethylethyl)-N-[3-[6-[[4-[[4-[6-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-4-yl]amino]acetyl]amino]hexyl]-1-piperazinyl]carbonyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]benzamide
Quantity:
5 mg
Molecular Formula:
C55H62N10O8
CAS:
2366132-45-6
Target:
Active Degraders
Purity:
0.98
Chemical Name or Material: __
Quantity: 1 g
Molecular Formula: __
CAS: __
Target: __
Purity: __
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Quantity:
1 g
Molecular Formula:
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Chemical Name or Material: __
Quantity: 1 Kit
Molecular Formula: __
CAS: __
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1 Kit
Molecular Formula:
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Chemical Name or Material: 1-Amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
Quantity: 10 mg
Molecular Formula: C20H13N5
CAS: 150651-39-1
Target: Other Reductase Inhibitors
Purity: 98%
Chemical Name or Material:
1-Amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
Quantity:
10 mg
Molecular Formula:
C20H13N5
CAS:
150651-39-1
Target:
Other Reductase Inhibitors
Purity:
98%