71-981-0
Tocris Bioscience™ JHU 37160
Manufacturer: Fischer Scientific
CAS Number: 2369979-68-8
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 71-981-0-Each-of-1 | In Stock | ₹ 23,896.50 |
71-981-0 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 23,896.50
GST (18%): ₹ 4,301.37
Total Price: ₹ 28,197.87
Chemical Name or Material
8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
Quantity
10 mg
Molecular Formula
C19H20ClFN4
CAS
2369979-68-8
Target
DREADD Activators
Purity
0.98
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ JHU 37160 | Fischer Scientific | -- | |
| | Tocris Bioscience™ JHU 37160 | Fischer Scientific | ₹ 1,00,570.00 | |
 | eMolecules Medchem Express / JHU37160 / 5mg / 596608116 / HY-131881 / / 2369979-68-8 / [null] / 358.850 / C19H20ClFN4 | eMolecules | ₹ 4,791.76 | |
 | JHU37160 | ChemScene | ₹ 3,115.00 - ₹ 21,805.00 | |
 | 2369979-68-8 | JHU 37160 | A2B Chem | ₹ 3,026.00 - ₹ 19,313.00 |
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Description
- JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.9 nM and 3.6 nM for hM3Dq and hM4Di in vitro , respectively; EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in vitro , respectively)
- Displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21 (Cat
- No
- 5548)
- Selectively displaces [3H]clozapine from DREADDs in vivo , but not from other clozapine binding sites
- Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons
- Brain penetrant in mice, rats and non-human primates.
SAFETY INFORMATION
- Recommended Storage : Store at RT
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Chemical Name or Material: 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
Quantity: 10 mg
Molecular Formula: C19H20ClFN4
CAS: 2369979-68-8
Target: DREADD Activators
Purity: 0.98
Chemical Name or Material:
8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
Quantity:
10 mg
Molecular Formula:
C19H20ClFN4
CAS:
2369979-68-8
Target:
DREADD Activators
Purity:
0.98
Chemical Name or Material: 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
Quantity: 50 mg
Molecular Formula: C19H20ClFN4
CAS: 2369979-68-8
Target: DREADD Activators
Purity: 0.98
Chemical Name or Material:
8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
Quantity:
50 mg
Molecular Formula:
C19H20ClFN4
CAS:
2369979-68-8
Target:
DREADD Activators
Purity:
0.98
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