7237105
Tocris Bioscience™ JHU 37160
High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
Manufacturer: Fischer Scientific
CAS Number: 2369979-68-8
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Chemical Name or Material
8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
Target
DREADD Activators
Purity
0.98
CAS
2369979-68-8
Molecular Formula
C19H20ClFN4
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ JHU 37160 | Fischer Scientific | ₹ 23,896.50 | |
| | Tocris Bioscience™ JHU 37160 | Fischer Scientific | ₹ 1,00,570.00 | |
 | eMolecules Medchem Express / JHU37160 / 5mg / 596608116 / HY-131881 / / 2369979-68-8 / [null] / 358.850 / C19H20ClFN4 | eMolecules | ₹ 4,791.76 | |
 | JHU37160 | ChemScene | ₹ 3,115.00 - ₹ 21,805.00 | |
 | 2369979-68-8 | JHU 37160 | A2B Chem | ₹ 3,026.00 - ₹ 19,313.00 |
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Description
- JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.9 nM and 3.6 nM for hM3Dq and hM4Di in vitro , respectively; EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in vitro , respectively)
- Displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21 (Cat
- No
- 5548)
- Selectively displaces [3H]clozapine from DREADDs in vivo , but not from other clozapine binding sites
- Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons
- Brain penetrant in mice, rats and non-human primates.
SAFETY INFORMATION
- Recommended Storage : Store at RT
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Chemical Name or Material: 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
Target: DREADD Activators
Purity: 0.98
CAS: 2369979-68-8
Molecular Formula: C19H20ClFN4
Chemical Name or Material:
8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
Target:
DREADD Activators
Purity:
0.98
CAS:
2369979-68-8
Molecular Formula:
C19H20ClFN4
Chemical Name or Material: (2 aR,5 aR,6 S,6 aR,8 R,9 aR,10 AS,10 bR,10 cR)-8-(3-Furanyl)-2 A,5 A,6,6 A,8,9,9 A,10 A,10 b,10 c-decahydro-2 A,5 A,6 A,7-tetramethyl-2,5-dioxo-2 H,5 H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester
Target: Ubiquitin Ligase (E3) Inhibitors
Purity: 0.97
CAS: 25990-37-8
Molecular Formula: C27H30O7
Chemical Name or Material:
(2 aR,5 aR,6 S,6 aR,8 R,9 aR,10 AS,10 bR,10 cR)-8-(3-Furanyl)-2 A,5 A,6,6 A,8,9,9 A,10 A,10 b,10 c-decahydro-2 A,5 A,6 A,7-tetramethyl-2,5-dioxo-2 H,5 H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester
Target:
Ubiquitin Ligase (E3) Inhibitors
Purity:
0.97
CAS:
25990-37-8
Molecular Formula:
C27H30O7
Chemical Name or Material: N-[3-[[5-(4-Chlorophenyl)-1 H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Target: Raf Kinase Inhibitors
Purity: 0.98
CAS: 918504-65-1
Molecular Formula: C23H18ClF2N3O3S
Chemical Name or Material:
N-[3-[[5-(4-Chlorophenyl)-1 H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Target:
Raf Kinase Inhibitors
Purity:
0.98
CAS:
918504-65-1
Molecular Formula:
C23H18ClF2N3O3S
Chemical Name or Material: Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7 ]dec-1-ylphenoxy)acetyl]amino]benzoate
Target: Dehydrogenase Inhibitors
Purity: 0.98
CAS: 934593-90-5
Molecular Formula: C26H29NO5
Chemical Name or Material:
Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7 ]dec-1-ylphenoxy)acetyl]amino]benzoate
Target:
Dehydrogenase Inhibitors
Purity:
0.98
CAS:
934593-90-5
Molecular Formula:
C26H29NO5