7223021
Tocris Bioscience™ SEN 177
Potent glutaminyl cyclase inhibitor; disrupts binding of SIRP-α to CD47
Manufacturer: Fischer Scientific
CAS Number: 2117405-13-5
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Chemical Name or Material
6 '-Fluoro-2-[4-(4-methyl-4 H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3 '-bipyridine
Target
Other Transferase Inhibitors
Purity
0.98
CAS
2117405-13-5
Molecular Formula
C18H19FN6
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ SEN 177 | Fischer Scientific | ₹ 16,016.83 | |
| | Tocris Bioscience™ SEN 177 | Fischer Scientific | ₹ 67,079.04 | |
 | 2117405-13-5 | 3-(6-FLUOROPYRIDIN-3-YL)-2-[4-(4-METHYL-4H-1,2,4-TRIAZOL-3-YL)PIPERIDIN-1-YL]PYRIDINE | A2B Chem | ₹ 3,850.20 - ₹ 30,202.68 |
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Description
- Description SEN 177 is a potent glutaminyl cyclase (QPCT) inhibitor (IC50 = 53 nM)
- SEN 177 reduces aggregation of mutant huntingtin (mHTT) through inhibition of QPCT and reduces Q80 aggregates in vitro
- Inhibition of QPCT also reduces aggregate formation in in vivo models of Huntington's disease
- SEN 177 potently inhibits QPCT-like protein (IC50 = 13 nM) and disrupts binding of SIRP-α to CD47
- The compound increases antibody-dependent cellular phagocytosis and cytotoxicity in cancer cell lines.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 6 '-Fluoro-2-[4-(4-methyl-4 H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3 '-bipyridine
Target: Other Transferase Inhibitors
Purity: 0.98
CAS: 2117405-13-5
Molecular Formula: C18H19FN6
Chemical Name or Material:
6 '-Fluoro-2-[4-(4-methyl-4 H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3 '-bipyridine
Target:
Other Transferase Inhibitors
Purity:
0.98
CAS:
2117405-13-5
Molecular Formula:
C18H19FN6
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