7249491
Tocris Bioscience™ C25-140
TRAF6-Ubc13 interaction inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1358099-18-9
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Chemical Name or Material
3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
CAS
1358099-18-9
Target
Ubiquitin Ligase (E3) Inhibitors
Molecular Formula
C26H31N7O
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ C25-140 | Fischer Scientific | ₹ 28,790.94 | |
| | Tocris Bioscience™ C25-140 | Fischer Scientific | ₹ 1,20,896.28 | |
 | Selleck Chemical LLC C25-140 5mg 1358099-18-9 | Selleck Chemical LLC | ₹ 19,199.66 | |
 | Medchemexpress LLC HY-120934 5mg Medchemexpress, C25-140 CAS:1358099-18-9 Purity:>98% | Medchemexpress LLC | ₹ 16,170.84 | |
| | eMolecules Medchem Express / C25-140 / 5mg / 455326192 / HY-120934 / / 1358099-18-9 / MFCD27163630 / 457.582 / C26H31N7O | eMolecules | ₹ 22,669.98 | |
 | 1358099-18-9 | C25-140 | A2B Chem | ₹ 3,080.16 - ₹ 46,459.08 |
Related Products
Description
- C25-140 binds directly to TNF receptor-associated factor 6 (TRAF6) and inhibits its interaction with ubiquitin-conjugating enzyme Ubc13
- C25-140 reduces TRAF6-Ubc13 activity and decreases NF-κB activation and inflammatory signaling in vitro
- C25-140 exhibits selectivity for TRAF6 over other E3 ligases except cIAP1
- In in vivo mouse models of autoimmune psoriasis and rheumatoid arthritis, the compound improves disease symptoms
- The compound also suppresses the pro-inflammatory signaling activity of IL-17A and prevents its inhibitory effect on the anti-HBV action of IFN-α HepG2 cells.
SAFETY INFORMATION
- Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Compare Similar Items
Show Difference
Chemical Name or Material: 3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
CAS: 1358099-18-9
Target: Ubiquitin Ligase (E3) Inhibitors
Molecular Formula: C26H31N7O
Chemical Name or Material:
3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
CAS:
1358099-18-9
Target:
Ubiquitin Ligase (E3) Inhibitors
Molecular Formula:
C26H31N7O
Chemical Name or Material: (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide
CAS: 1393477-72-9
Target: Antiviral Compounds
Molecular Formula: C17H11F6N7O
Chemical Name or Material:
(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide
CAS:
1393477-72-9
Target:
Antiviral Compounds
Molecular Formula:
C17H11F6N7O
Chemical Name or Material: N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
CAS: 2083627-02-3
Target: EED
Molecular Formula: C17H15N5O3S
Chemical Name or Material:
N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
CAS:
2083627-02-3
Target:
EED
Molecular Formula:
C17H15N5O3S
Chemical Name or Material: 3-Chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
CAS: 612542-14-0
Target: Smoothened
Molecular Formula: C28H26ClF2N3OS
Chemical Name or Material:
3-Chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
CAS:
612542-14-0
Target:
Smoothened
Molecular Formula:
C28H26ClF2N3OS