7250112
Tocris Bioscience™ Verdinexor
Selective exportin-1 (XPO1/CRM1) inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1392136-43-4
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Chemical Name or Material
(2 Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1 H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyridinyl)hydrazide
Target
Antiviral Compounds
Purity
0.98
CAS
1392136-43-4
Molecular Formula
C18H12F6N6O
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ Verdinexor | Fischer Scientific | ₹ 18,559.68 | |
| | Tocris Bioscience™ Verdinexor | Fischer Scientific | ₹ 77,613.19 | |
 | Selleck Chemical LLC Verdinexor (KPT-335) 5mg 1392136-43-4 ATG-527 | Selleck Chemical LLC | ₹ 20,226.38 | |
 | eMolecules AstaTech / KPT335 / 5mg / 562547058 / 40840 / 95.000 / 1392136-43-4 / MFCD28167840 / 442.325 / C18H12F6N6O | eMolecules | ₹ 37,657.52 |
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Description
- Verdinexor is a selective exportin-1 (XPO1/CRM1) inhibitor
- It potently inhibits influenza virus ribonucleoprotein (vRNP) export by disrupting XPO1-NEP binding and the replication of influenza virus A and B strains in vitro , including H1N1, H5N1 and H7N9 (IC50 values in the range 40 - 420 nM range)
- Verdinexor limits influenza A virus spread in mouse lung in vivo
- In neuroblastoma, verdinexor suppresses cell proliferation and induces cell apoptosis
- It also induces P53 nuclear accumulation and induces G0/G1 phase cell cycle arrest by activating P53 function
- Verdinexor inhibits tumor growth in in vivo mouse models
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: (2 Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1 H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyridinyl)hydrazide
Target: Antiviral Compounds
Purity: 0.98
CAS: 1392136-43-4
Molecular Formula: C18H12F6N6O
Chemical Name or Material:
(2 Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1 H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyridinyl)hydrazide
Target:
Antiviral Compounds
Purity:
0.98
CAS:
1392136-43-4
Molecular Formula:
C18H12F6N6O
Chemical Name or Material: N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4 ]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine
Target: EGF Receptor Inhibitors
Purity: 0.98
CAS: 937263-43-9
Molecular Formula: C26H24N8O2
Chemical Name or Material:
N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4 ]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine
Target:
EGF Receptor Inhibitors
Purity:
0.98
CAS:
937263-43-9
Molecular Formula:
C26H24N8O2
Chemical Name or Material: N-[[(1 R,2 R)-2-(2,3-Dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide
Target: Melatonin (MT) Receptor Agonists
Purity: 0.98
CAS: 609799-22-6
Molecular Formula: C15H19NO2
Chemical Name or Material:
N-[[(1 R,2 R)-2-(2,3-Dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide
Target:
Melatonin (MT) Receptor Agonists
Purity:
0.98
CAS:
609799-22-6
Molecular Formula:
C15H19NO2
Chemical Name or Material: 8,8 '-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide]
Target: Proteasome Inhibitors
Purity: 0.98
CAS: 2084868-04-0
Molecular Formula: C30H24N6O2S4
Chemical Name or Material:
8,8 '-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide]
Target:
Proteasome Inhibitors
Purity:
0.98
CAS:
2084868-04-0
Molecular Formula:
C30H24N6O2S4