7237103
Tocris Bioscience™ Deschloroclozapine
High affinity and highly potent activator of hM3Dq and hM4Di DREADDs; rapidly blood brain barrier penetrant
Manufacturer: Fischer Scientific
CAS Number: 1977-07-07 00:00:00
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Chemical Name or Material
11-(4-Methyl-1-piperazinyl)-5 H-dibenzo[b,e][1,4 ]diazepine
Target
DREADD Activators
Purity
0.98
CAS
1977-07-07 00:00:00
Molecular Formula
C18H20N4
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ Deschloroclozapine | Fischer Scientific | ₹ 15,537.70 | |
| | Tocris Bioscience™ Deschloroclozapine | Fischer Scientific | ₹ 65,367.84 |
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Description
- Deschloroclozapine is a high affinity and highly potent activator of muscarinic DREADDs (Ki values are 6.3 nM for hM3Dq and 4.2 nM for hM4Di, in vitro ; EC50 values are 0.13 nM for hM3Dq and 0.081 nM for hM4Di, in vitro )
- Derivative of clozapine (Cat
- No
- 0444)
- Exhibits 100-fold greater affinity for hM3Dq and hM4Di compared to clozapine N -oxide (CNO; Cat
- No
- 4936), and 50-fold greater affinity compared to DREADD agonist 21 (Cat
- No
- 5548)
- Displays low 'off-target' receptor binding (Ki >100 nM at majority of GPCRs, ion channels and transporters tested)
- Displays rapid (approx
- 10 minutes after i.p injection) binding and activation of hM3Dq and hM4Di in mice and non-human primates
- Induces spatial memory deficits in non-human primates expressing hM4Di in the prefrontal cortex.
SAFETY INFORMATION
- Recommended Storage : Store at RT
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Show Difference
Chemical Name or Material: 11-(4-Methyl-1-piperazinyl)-5 H-dibenzo[b,e][1,4 ]diazepine
Target: DREADD Activators
Purity: 0.98
CAS: 1977-07-07 00:00:00
Molecular Formula: C18H20N4
Chemical Name or Material:
11-(4-Methyl-1-piperazinyl)-5 H-dibenzo[b,e][1,4 ]diazepine
Target:
DREADD Activators
Purity:
0.98
CAS:
1977-07-07 00:00:00
Molecular Formula:
C18H20N4
Chemical Name or Material: 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
Target: DREADD Activators
Purity: 0.98
CAS: 2369979-68-8
Molecular Formula: C19H20ClFN4
Chemical Name or Material:
8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
Target:
DREADD Activators
Purity:
0.98
CAS:
2369979-68-8
Molecular Formula:
C19H20ClFN4
Chemical Name or Material: (2 aR,5 aR,6 S,6 aR,8 R,9 aR,10 AS,10 bR,10 cR)-8-(3-Furanyl)-2 A,5 A,6,6 A,8,9,9 A,10 A,10 b,10 c-decahydro-2 A,5 A,6 A,7-tetramethyl-2,5-dioxo-2 H,5 H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester
Target: Ubiquitin Ligase (E3) Inhibitors
Purity: 0.97
CAS: 25990-37-8
Molecular Formula: C27H30O7
Chemical Name or Material:
(2 aR,5 aR,6 S,6 aR,8 R,9 aR,10 AS,10 bR,10 cR)-8-(3-Furanyl)-2 A,5 A,6,6 A,8,9,9 A,10 A,10 b,10 c-decahydro-2 A,5 A,6 A,7-tetramethyl-2,5-dioxo-2 H,5 H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester
Target:
Ubiquitin Ligase (E3) Inhibitors
Purity:
0.97
CAS:
25990-37-8
Molecular Formula:
C27H30O7
Chemical Name or Material: N-[3-[[5-(4-Chlorophenyl)-1 H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Target: Raf Kinase Inhibitors
Purity: 0.98
CAS: 918504-65-1
Molecular Formula: C23H18ClF2N3O3S
Chemical Name or Material:
N-[3-[[5-(4-Chlorophenyl)-1 H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Target:
Raf Kinase Inhibitors
Purity:
0.98
CAS:
918504-65-1
Molecular Formula:
C23H18ClF2N3O3S