7237107
Tocris Bioscience™ Nimbolide
RNF114 inhibitor
Manufacturer: Fischer Scientific
CAS Number: 25990-37-8
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Chemical Name or Material
(2 aR,5 aR,6 S,6 aR,8 R,9 aR,10 AS,10 bR,10 cR)-8-(3-Furanyl)-2 A,5 A,6,6 A,8,9,9 A,10 A,10 b,10 c-decahydro-2 A,5 A,6 A,7-tetramethyl-2,5-dioxo-2 H,5 H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester
Target
Ubiquitin Ligase (E3) Inhibitors
Purity
0.97
CAS
25990-37-8
Molecular Formula
C27H30O7
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ Nimbolide | Fischer Scientific | ₹ 1,28,938.92 | |
| | Tocris Bioscience™ Nimbolide | Fischer Scientific | ₹ 30,887.16 | |
 | eMolecules Medchem Express / Nimbolide / 5mg / 599423733 / HY-116035 / / 25990-37-8 / [null] / 466.530 / C27H30O7 | eMolecules | ₹ 35,264.41 | |
 | Medchemexpress LLC HY-116035 5mg , Nimbolide CAS:25990-37-8 Purity:>98% | Medchemexpress LLC | ₹ 25,154.64 | |
| | Nimbolide | Sigma Aldrich | ₹ 1,69,627.75 | |
 | Nimbolide | Sigma Aldrich | ₹ 38,807.63 | |
 | 25990-37-8 | Nimbolide | A2B Chem | ₹ 19,336.56 - ₹ 81,538.68 |
Related Products
Description
- Nimbolide inhibits auto-ubiquitination of the E3 ligase RNF114 and p21 ubiquitination in vitro
- This compound impairs proliferation of triple-negative breast cancer cell lines
- Nimbolide also induces apoptotic cell death in a Waldenströms macroglobulinemia cell line (BCWM1) and inhibits tumor growth in a xenograft model of Waldenströms macroglobulinemia
- Nimbolide can be used for the development of Degraders that utilize RNF114 as an E3 ligase for Targeted Protein Degradation.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: (2 aR,5 aR,6 S,6 aR,8 R,9 aR,10 AS,10 bR,10 cR)-8-(3-Furanyl)-2 A,5 A,6,6 A,8,9,9 A,10 A,10 b,10 c-decahydro-2 A,5 A,6 A,7-tetramethyl-2,5-dioxo-2 H,5 H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester
Target: Ubiquitin Ligase (E3) Inhibitors
Purity: 0.97
CAS: 25990-37-8
Molecular Formula: C27H30O7
Chemical Name or Material:
(2 aR,5 aR,6 S,6 aR,8 R,9 aR,10 AS,10 bR,10 cR)-8-(3-Furanyl)-2 A,5 A,6,6 A,8,9,9 A,10 A,10 b,10 c-decahydro-2 A,5 A,6 A,7-tetramethyl-2,5-dioxo-2 H,5 H-cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid methyl ester
Target:
Ubiquitin Ligase (E3) Inhibitors
Purity:
0.97
CAS:
25990-37-8
Molecular Formula:
C27H30O7
Chemical Name or Material: N-[3-[[5-(4-Chlorophenyl)-1 H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Target: Raf Kinase Inhibitors
Purity: 0.98
CAS: 918504-65-1
Molecular Formula: C23H18ClF2N3O3S
Chemical Name or Material:
N-[3-[[5-(4-Chlorophenyl)-1 H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Target:
Raf Kinase Inhibitors
Purity:
0.98
CAS:
918504-65-1
Molecular Formula:
C23H18ClF2N3O3S
Chemical Name or Material: Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7 ]dec-1-ylphenoxy)acetyl]amino]benzoate
Target: Dehydrogenase Inhibitors
Purity: 0.98
CAS: 934593-90-5
Molecular Formula: C26H29NO5
Chemical Name or Material:
Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7 ]dec-1-ylphenoxy)acetyl]amino]benzoate
Target:
Dehydrogenase Inhibitors
Purity:
0.98
CAS:
934593-90-5
Molecular Formula:
C26H29NO5
Chemical Name or Material: (2 S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
Target: Cyclin-dependent Kinase Inhibitors
Purity: 0.98
CAS: 779353-01-4
Molecular Formula: C21H28N6O2
Chemical Name or Material:
(2 S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
Target:
Cyclin-dependent Kinase Inhibitors
Purity:
0.98
CAS:
779353-01-4
Molecular Formula:
C21H28N6O2