7237109
Tocris Bioscience™ Vemurafenib
Potent BRAF and CRAF inhibitor
Manufacturer: Fischer Scientific
CAS Number: 918504-65-1
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Chemical Name or Material
N-[3-[[5-(4-Chlorophenyl)-1 H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Target
Raf Kinase Inhibitors
Purity
0.98
CAS
918504-65-1
Molecular Formula
C23H18ClF2N3O3S
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Description
- Vemurafenib is a potent inhibitor of BRAFV600E, C-Raf and wild type B-Raf (IC50 values are 13-31 nM, 6.7-48 nM and 100-160 nM, respectively
- Vemurafenib also inhibits SRMS, ACK1 KHS1, FGR (IC50 values are 18 nM, 19 nM, 51 nM and 63 nM, respectively)
- Vemurafenib shows antitumor activity and induces autophagy in BRAF-mutant thyroid cancer cells.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: N-[3-[[5-(4-Chlorophenyl)-1 H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Target: Raf Kinase Inhibitors
Purity: 0.98
CAS: 918504-65-1
Molecular Formula: C23H18ClF2N3O3S
Chemical Name or Material:
N-[3-[[5-(4-Chlorophenyl)-1 H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Target:
Raf Kinase Inhibitors
Purity:
0.98
CAS:
918504-65-1
Molecular Formula:
C23H18ClF2N3O3S
Chemical Name or Material: Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7 ]dec-1-ylphenoxy)acetyl]amino]benzoate
Target: Dehydrogenase Inhibitors
Purity: 0.98
CAS: 934593-90-5
Molecular Formula: C26H29NO5
Chemical Name or Material:
Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7 ]dec-1-ylphenoxy)acetyl]amino]benzoate
Target:
Dehydrogenase Inhibitors
Purity:
0.98
CAS:
934593-90-5
Molecular Formula:
C26H29NO5
Chemical Name or Material: (2 S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
Target: Cyclin-dependent Kinase Inhibitors
Purity: 0.98
CAS: 779353-01-4
Molecular Formula: C21H28N6O2
Chemical Name or Material:
(2 S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
Target:
Cyclin-dependent Kinase Inhibitors
Purity:
0.98
CAS:
779353-01-4
Molecular Formula:
C21H28N6O2
Chemical Name or Material: N-[(1 Z)-1-[[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]carbonyl]-2-phenylethenyl]benzamide
Target: DNA, RNA and Protein Synthesis Inhibitors
Purity: 0.98
CAS: 2141978-86-9
Molecular Formula: C27H25BrN2O3
Chemical Name or Material:
N-[(1 Z)-1-[[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]carbonyl]-2-phenylethenyl]benzamide
Target:
DNA, RNA and Protein Synthesis Inhibitors
Purity:
0.98
CAS:
2141978-86-9
Molecular Formula:
C27H25BrN2O3