7166800
Tocris™ Omipalisib
Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK
Manufacturer: Fischer Scientific
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Chemical Name or Material
2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
Molecular Formula
C25H17F2N5O3S
Product Type
Inhibitor
Synonym
GSK2126458
Formula Weight
505.5
Purity
98%
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Description
- Omipalisib is a highly potent PI 3-K inhibitor (IC50 = 0.04 nM)
- Also inhibits mTOR (Ki = 0.18 - 0.3 nM) and DNA-PK (IC50 = 0.28 nM)
- Induces G1 cell cycle arrest and inhibits proliferation of some breast cancer cells lines in vitro
- Reduces pAKT-S473 levels in and inhibits growth of BT474 breast cancer xenografts in mice
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
Molecular Formula: C25H17F2N5O3S
Product Type: Inhibitor
Synonym: GSK2126458
Formula Weight: 505.5
Purity: 98%
Chemical Name or Material:
2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
Molecular Formula:
C25H17F2N5O3S
Product Type:
Inhibitor
Synonym:
GSK2126458
Formula Weight:
505.5
Purity:
98%
Chemical Name or Material: __
Molecular Formula: C16H11BrN2O2
Product Type: Inhibitor
Synonym: __
Formula Weight: 343.18
Purity: 98%
Chemical Name or Material:
__
Molecular Formula:
C16H11BrN2O2
Product Type:
Inhibitor
Synonym:
__
Formula Weight:
343.18
Purity:
98%
Chemical Name or Material: __
Molecular Formula: C9H12N6O4
Product Type: Inhibitor
Synonym: __
Formula Weight: 268.23
Purity: 98%
Chemical Name or Material:
__
Molecular Formula:
C9H12N6O4
Product Type:
Inhibitor
Synonym:
__
Formula Weight:
268.23
Purity:
98%
Chemical Name or Material: __
Molecular Formula: C18H15NO4
Product Type: Positive Allosteric Modulator
Synonym: __
Formula Weight: 309.32
Purity: 98%
Chemical Name or Material:
__
Molecular Formula:
C18H15NO4
Product Type:
Positive Allosteric Modulator
Synonym:
__
Formula Weight:
309.32
Purity:
98%