7224938
Tocris Bioscience™ Pexidartinib
Potent CSF-1R inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1029044-16-3
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Chemical Name or Material
N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Target
Additional RTK Inhibitors
Purity
98%
CAS
1029044-16-3
Molecular Formula
C20H15ClF3N5
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Description
- Pexidartinib is a potent colony-stimulating factor-1 receptor (CSF-1R) tyrosine kinase inhibitor (IC50 = 20 nM)
- In the B16F10 mouse melanoma model, Pexidartinib reduces the systemic and local accumulation of macrophages without affecting Gr-1+ myeloid derived suppressor cells
- When combined with tumor-specific CD8 T cell immunotherapy, Pexidartinib promotes the control of tumor growth
- In the BRAFV600E-driven mouse melanoma model, Pexidartinib improves the efficacy of adoptive cell therapy with reduction of TIMs and an increase in tumor-infiltrating lymphocytes and T cells
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Target: Additional RTK Inhibitors
Purity: 98%
CAS: 1029044-16-3
Molecular Formula: C20H15ClF3N5
Chemical Name or Material:
N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Target:
Additional RTK Inhibitors
Purity:
98%
CAS:
1029044-16-3
Molecular Formula:
C20H15ClF3N5
Chemical Name or Material: β-D-N4-hydroxycytidine-5 '-isopropyl ester
Target: Antiviral Compounds
Purity: 98%
CAS: 2492423-29-5
Molecular Formula: C13H19N3O7
Chemical Name or Material:
β-D-N4-hydroxycytidine-5 '-isopropyl ester
Target:
Antiviral Compounds
Purity:
98%
CAS:
2492423-29-5
Molecular Formula:
C13H19N3O7
Chemical Name or Material: (3 R,4 S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide
Target: Nrf2 Activators
Purity: 98%
CAS: 2416095-06-0
Molecular Formula: C14H20ClNO4S2
Chemical Name or Material:
(3 R,4 S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide
Target:
Nrf2 Activators
Purity:
98%
CAS:
2416095-06-0
Molecular Formula:
C14H20ClNO4S2
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