7110855
Tocris Bioscience™ GS 143
β-TrCP1 ligase inhibitor
Manufacturer: Fischer Scientific
CAS Number: 916232-21-8
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Chemical Name or Material
4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid
Target
Ubiquitin Ligase (E3) Inhibitors
Formula Weight
466.46
CAS
916232-21-8
Molecular Formula
C28H19FN2O4
Purity
>98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ GS 143 | -- | ₹ 23,985.50 | ||
Tocris Bioscience™ GS 143 | -- | ₹ 1,00,125.00 | ||
eMolecules Medchem Express / GS143 / 5mg / 552386433 / HY-110261 / / 916232-21-8 / MFCD30182334 / 466.468 / C28H19FN2O4 | -- | ₹ 14,410.88 | ||
916232-21-8 | 4-(3-Benzyl-4-{[5-(2-fluorophenyl)furan-2-yl]methylidene}-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid | -- | ₹ 8,544.00 - ₹ 13,439.00 |
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Description
- β-TrCP1 ligase inhibitor
- Inhibits IκBα ubiquitination (IC50 = 5.2 μM) without affecting proteasome activity
- Blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells
- Suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C