7110855
Tocris Bioscience™ GS 143
β-TrCP1 ligase inhibitor
Manufacturer: Fischer Scientific
CAS Number: 916232-21-8
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Chemical Name or Material
4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid
Target
Ubiquitin Ligase (E3) Inhibitors
Formula Weight
466.46
CAS
916232-21-8
Molecular Formula
C28H19FN2O4
Purity
>98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ GS 143 | Fischer Scientific | ₹ 23,058.42 | |
| | Tocris Bioscience™ GS 143 | Fischer Scientific | ₹ 96,255.00 | |
 | eMolecules Medchem Express / GS143 / 5mg / 552386433 / HY-110261 / / 916232-21-8 / MFCD30182334 / 466.468 / C28H19FN2O4 | eMolecules | ₹ 13,853.88 | |
 | 916232-21-8 | 4-(3-Benzyl-4-{[5-(2-fluorophenyl)furan-2-yl]methylidene}-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid | A2B Chem | ₹ 8,213.76 - ₹ 12,919.56 |
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Description
- β-TrCP1 ligase inhibitor
- Inhibits IκBα ubiquitination (IC50 = 5.2 μM) without affecting proteasome activity
- Blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells
- Suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C
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Chemical Name or Material: 4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid
Target: Ubiquitin Ligase (E3) Inhibitors
Formula Weight: 466.46
CAS: 916232-21-8
Molecular Formula: C28H19FN2O4
Purity: >98%
Chemical Name or Material:
4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid
Target:
Ubiquitin Ligase (E3) Inhibitors
Formula Weight:
466.46
CAS:
916232-21-8
Molecular Formula:
C28H19FN2O4
Purity:
>98%
Chemical Name or Material: N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide
Target: ASK1 Inhibitors
Formula Weight: 362.31
CAS: 1124381-43-6
Molecular Formula: C16H13F3N6O
Purity: >98%
Chemical Name or Material:
N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide
Target:
ASK1 Inhibitors
Formula Weight:
362.31
CAS:
1124381-43-6
Molecular Formula:
C16H13F3N6O
Purity:
>98%
Chemical Name or Material: 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Target: Histone Acetyltransferase Inhibitors
Formula Weight: 440.49
CAS: 1675821-32-5
Molecular Formula: C27H24N2O4
Purity: >98%
Chemical Name or Material:
5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Target:
Histone Acetyltransferase Inhibitors
Formula Weight:
440.49
CAS:
1675821-32-5
Molecular Formula:
C27H24N2O4
Purity:
>98%
Chemical Name or Material: 2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate
Target: Autophagy-related Compounds
Formula Weight: 433.95
CAS: 747-36-4
Molecular Formula: C18H28ClN3O5S
Purity: >99%
Chemical Name or Material:
2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]ethylamino]ethanol sulfate
Target:
Autophagy-related Compounds
Formula Weight:
433.95
CAS:
747-36-4
Molecular Formula:
C18H28ClN3O5S
Purity:
>99%