7110905

Tocris Bioscience™ DEL 22379

ERK dimerization inhibitor

Manufacturer: Fischer Scientific

CAS Number: 181223-80-3

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Chemical Name or Material

N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide

Target

ERK Inhibitors

Formula Weight

444.53

CAS

181223-80-3

Molecular Formula

C26H28N4O3

Purity

>98%

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Description

  • ERK dimerization inhibitor (IC50 ∽ 0.5 μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity
  • Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro
  • Induces apoptosis and prevents tumor progression in vivo .

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C