7110906

Tocris Bioscience™ AZ 6102

Potent TNKS1/2 inhibitor

Manufacturer: Fischer Scientific

CAS Number: 1645286-75-4

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Chemical Name or Material

rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one

Target

Tankyrase Inhibitors

Formula Weight

428.53

CAS

1645286-75-4

Molecular Formula

C25H28N6O

Purity

>98%

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Description

  • Potent TNKS2 and TNKS1 inhibitor (IC50 values are 1 and 3 nM, respectively)
  • Exhibits >100-fold selectivity for TNKS1/2 over PARP-1, PARP-2 and PARP-6
  • Inhibits Wnt signaling in DLD-1 cells (IC50 = 5 nM)
  • Exhibits moderate oral bioavailability.

SAFETY INFORMATION

  • Recommended Storage : Store at -20°C