7110939
Tocris Bioscience™ PF 05089771
Potent and selective Nav1.7 channel blocker
Manufacturer: Fischer Scientific
CAS Number: 1430806-04-4
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Chemical Name or Material
4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate
Target
Voltage-gated Sodium Channel Blockers
Formula Weight
672.56
CAS
1430806-04-4
Molecular Formula
C18H12Cl2FN5O3S2.C7H8O3S
Purity
>98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ PF 05089771 | Fischer Scientific | ₹ 22,288.38 | |
| | Tocris Bioscience™ PF 05089771 | Fischer Scientific | ₹ 92,148.12 | |
 | 1430806-04-4 | 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamidetosylate | A2B Chem | ₹ 7,187.04 - ₹ 89,495.76 |
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Description
- Potent and selective Nav1.7 channel blocker (IC50 = 8, 11 and 171 nM for mouse, human and rat Nav1.7, respectively)
- Exhibits selectivity for Nav1.7 over other Nav1 channels (IC50 values are 0.11, 0.16, 0.85, 10, 11 and 25 μM for Nav1.2, Nav1.6, Nav1.1, Nav1.4, Nav1.3 and Nav1.5, respectively)
- Also exhibits selectivity over a panel of 81 other ion channels, receptors, enzymes and transporters
- Blocks spontaneous firing of inherited erythromelalgia (IEM)-derived iPSC sensory neurons in vitro .
SAFETY INFORMATION
- Recommended Storage : Desiccate at Room Temperature
Compare Similar Items
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Chemical Name or Material: 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate
Target: Voltage-gated Sodium Channel Blockers
Formula Weight: 672.56
CAS: 1430806-04-4
Molecular Formula: C18H12Cl2FN5O3S2.C7H8O3S
Purity: >98%
Chemical Name or Material:
4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate
Target:
Voltage-gated Sodium Channel Blockers
Formula Weight:
672.56
CAS:
1430806-04-4
Molecular Formula:
C18H12Cl2FN5O3S2.C7H8O3S
Purity:
>98%
Chemical Name or Material: 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
Target: LXR-like Receptor Agonists
Formula Weight: 422.78
CAS: 875787-07-8
Molecular Formula: C21H12ClF5N2
Purity: >98%
Chemical Name or Material:
2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
Target:
LXR-like Receptor Agonists
Formula Weight:
422.78
CAS:
875787-07-8
Molecular Formula:
C21H12ClF5N2
Purity:
>98%
Chemical Name or Material: 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Target: Hydrolase Inhibitors
Formula Weight: 377.82
CAS: 385786-48-1
Molecular Formula: C21H16ClN3O2
Purity: >97%
Chemical Name or Material:
7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Target:
Hydrolase Inhibitors
Formula Weight:
377.82
CAS:
385786-48-1
Molecular Formula:
C21H16ClN3O2
Purity:
>97%
Chemical Name or Material: α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid
Target: Additional Synthetic Protease Inhibitors
Formula Weight: 439.38
CAS: 393105-53-8
Molecular Formula: C24H16F3NO4
Purity: >98%
Chemical Name or Material:
α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid
Target:
Additional Synthetic Protease Inhibitors
Formula Weight:
439.38
CAS:
393105-53-8
Molecular Formula:
C24H16F3NO4
Purity:
>98%