7199105
Tocris™ Chroman 1
Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogeneisis
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Chemical Name or Material
(3 S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1 H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2 H-1-benzopyran-3-carboxamide dihydrochloride
Target
Rho-kinase Inhibitors
Molecular Formula
C24H28N4O40.2 HCl
Purity
98%
Related Products
Description
- Chroman 1 is a highly potent and selective ROCK2 (Rho-kinase) inhibitor (IC50 values are 1 and 52 pM at ROCK2 and ROCK1, respectively)
- Chroman 1 exhibits >2000-fold selectivity for ROCK2 over a range of related kinases including MRCK, PKA, and AKT1 (IC50 values are 150, >20000, and >20000 nM, respectively)
- Chroman 1 promotes survival of pluripotent stem cells (PSCs) in culture when used in combination with Emricasan (Cat
- No
- 7310), Polyamines, and Trans-ISRIB (Cat
- No
- 5284), a combination known as CEPT
- When used as part of the CEPT cocktail, Chroman 1 also improves survival of differentiated cells following cryopreservation with cardiomyocyte cell survival increasing by 36% and motor neuron survival improving by 63% compared with DMSO controls.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: (3 S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1 H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2 H-1-benzopyran-3-carboxamide dihydrochloride
Target: Rho-kinase Inhibitors
Molecular Formula: C24H28N4O40.2 HCl
Purity: 98%
Chemical Name or Material:
(3 S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1 H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2 H-1-benzopyran-3-carboxamide dihydrochloride
Target:
Rho-kinase Inhibitors
Molecular Formula:
C24H28N4O40.2 HCl
Purity:
98%
Chemical Name or Material: (3 AS)-2-[(3 S)-1-azabicyclo[2.2.2 ]oct-3-yl]-2,3,3 A,4,5,6-hexahydro-1 H-benz[de]isoquinolin-1-one hydrochloride
Target: 5-HT3 Receptor Antagonists
Molecular Formula: C19H24N2O.HCl
Purity: 98%
Chemical Name or Material:
(3 AS)-2-[(3 S)-1-azabicyclo[2.2.2 ]oct-3-yl]-2,3,3 A,4,5,6-hexahydro-1 H-benz[de]isoquinolin-1-one hydrochloride
Target:
5-HT3 Receptor Antagonists
Molecular Formula:
C19H24N2O.HCl
Purity:
98%
Chemical Name or Material: (2 Z)-2 [[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5 H-imidazo[2,1-b][1,3 ]thiazin-3(2 H)-one
Target: Additional Cannabinoid-related Compounds
Molecular Formula: C20H17ClN2O2S
Purity: 98%
Chemical Name or Material:
(2 Z)-2 [[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5 H-imidazo[2,1-b][1,3 ]thiazin-3(2 H)-one
Target:
Additional Cannabinoid-related Compounds
Molecular Formula:
C20H17ClN2O2S
Purity:
98%
Chemical Name or Material: N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine
Target: PDGF Receptor Inhibitors
Molecular Formula: C18H16FN3O2
Purity: 98%
Chemical Name or Material:
N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine
Target:
PDGF Receptor Inhibitors
Molecular Formula:
C18H16FN3O2
Purity:
98%