7249487
Tocris Bioscience™ UNC 6934
Antagonizes PWWP1 interaction with nucleosomal H3K36me2, alters NSD2 nucleolar localization
Manufacturer: Fischer Scientific
CAS Number: 2561494-77-5
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Chemical Name or Material
N-Cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide
CAS
2561494-77-5
Target
Lysine Methyltransferase Inhibitors
Molecular Formula
C24H21N5O4
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ UNC 6934 | Fischer Scientific | ₹ 1,05,105.33 | |
| | Tocris Bioscience™ UNC 6934 | Fischer Scientific | -- | |
| | eMolecules Medchem Express / UNC6934 / 5mg / 705861071 / HY-145103 / / 2561494-77-5 / [null] / 443.463 / C24H21N5O4 | eMolecules | ₹ 28,967.19 | |
 | N-Cyclopropyl-3-oxo-N-[4-(4-pyrimidinylcarbamoyl)benzyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide | Aaron Chemicals LLC | ₹ 36,876.36 - ₹ 1,17,816.12 |
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Description
- UNC 6934 binds to the N-terminal proline-tryptophan-tryptophan-proline (PWWP) domain of nuclear receptor-binding SET domain-containing 2 (NSD2)
- UNC 6934 inhibits PWWP1 interaction with nucleosomal H3K36me2 (IC50 = 104 nM) by occupying the canonical H3K36me2-binding pocket of PWWP1
- It selectively binds endogenous NSD2 in cells and causes accumulation of endogenous NSD2 in the nucleolus.
SAFETY INFORMATION
- Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Compare Similar Items
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Chemical Name or Material: N-Cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide
CAS: 2561494-77-5
Target: Lysine Methyltransferase Inhibitors
Molecular Formula: C24H21N5O4
Chemical Name or Material:
N-Cyclopropyl-3,4-dihydro-3-oxo-N-[[4-[(4-pyrimidinylamino)carbonyl]phenyl]methyl]-2H-1,4-benzoxazine-7-carboxamide
CAS:
2561494-77-5
Target:
Lysine Methyltransferase Inhibitors
Molecular Formula:
C24H21N5O4
Chemical Name or Material: N-[3-(Aminosulfonyl)-4-(3-chlorophenoxy)phenyl]benzeneacetamide
CAS: 2055602-83-8
Target: P2X4
Molecular Formula: C20H17ClN2O4S
Chemical Name or Material:
N-[3-(Aminosulfonyl)-4-(3-chlorophenoxy)phenyl]benzeneacetamide
CAS:
2055602-83-8
Target:
P2X4
Molecular Formula:
C20H17ClN2O4S
Chemical Name or Material: N-[4-(3,5-Dimethylphenyl)-5-(4-pyridinyl)-2-thiazolyl]-3-pyridinecarboxamide dihydrochloride
CAS: 325767-87-1
Target: Adenosine A3 R
Molecular Formula: C22H18N4OS.2HCl
Chemical Name or Material:
N-[4-(3,5-Dimethylphenyl)-5-(4-pyridinyl)-2-thiazolyl]-3-pyridinecarboxamide dihydrochloride
CAS:
325767-87-1
Target:
Adenosine A3 R
Molecular Formula:
C22H18N4OS.2HCl
Chemical Name or Material: 3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
CAS: 1358099-18-9
Target: Ubiquitin Ligase (E3) Inhibitors
Molecular Formula: C26H31N7O
Chemical Name or Material:
3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
CAS:
1358099-18-9
Target:
Ubiquitin Ligase (E3) Inhibitors
Molecular Formula:
C26H31N7O