7112875
Tocris Bioscience™ Ki 8751
Potent, selective VEGFR-2 inhibitor
Manufacturer: Fischer Scientific
CAS Number: 228559-41-9
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Chemical Name or Material
N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea
Assay Percent Range
>97%
Molecular Formula
C24H18F3N3O4
CAS
228559-41-9
Solubility
Soluble to 100mM in DMSO
Formula Weight
Observed MW: 469.41
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ Ki 8751 | Fischer Scientific | ₹ 1,21,837.44 | |
 | Tocris Bioscience™ Ki 8751 | Fischer Scientific | ₹ 29,090.40 | |
 | eMolecules Medchem Express / Ki8751 / 10mg / 446260590 / HY-12038 / / 228559-41-9 / MFCD09971092 / 469.420 / C24H18F3N3O4 | eMolecules | ₹ 12,720.21 | |
 | Selleck Chemical LLC Ki8751 5mg 228559-41-9 | Selleck Chemical LLC | ₹ 7,187.04 | |
 | 228559-41-9 | Ki8751 | A2B Chem | ₹ 4,363.56 - ₹ 79,228.56 |
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Description
- Potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM)
- Displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC50 > 10000 nM for FGFR-2, EGFR and HGFR)
- Inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo ; antiangiogenic.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C
Compare Similar Items
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Chemical Name or Material: N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea
Assay Percent Range: >97%
Molecular Formula: C24H18F3N3O4
CAS: 228559-41-9
Solubility: Soluble to 100mM in DMSO
Formula Weight: Observed MW: 469.41
Chemical Name or Material:
N-(2,4-Difluorophenyl)-N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea
Assay Percent Range:
>97%
Molecular Formula:
C24H18F3N3O4
CAS:
228559-41-9
Solubility:
Soluble to 100mM in DMSO
Formula Weight:
Observed MW: 469.41
Chemical Name or Material: (4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide
Assay Percent Range: >99%
Molecular Formula: C11H14BrNO2.HBr
CAS: 912342-28-0
Solubility: Soluble to 100mM in DMSO
Formula Weight: Observed MW: 353.05
Chemical Name or Material:
(4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide
Assay Percent Range:
>99%
Molecular Formula:
C11H14BrNO2.HBr
CAS:
912342-28-0
Solubility:
Soluble to 100mM in DMSO
Formula Weight:
Observed MW: 353.05
Chemical Name or Material: 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid
Assay Percent Range: >98%
Molecular Formula: C24H16BrFN2O4
CAS: 853929-59-6
Solubility: Soluble to 10mM in DMSO
Formula Weight: Observed MW: 495.3
Chemical Name or Material:
2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid
Assay Percent Range:
>98%
Molecular Formula:
C24H16BrFN2O4
CAS:
853929-59-6
Solubility:
Soluble to 10mM in DMSO
Formula Weight:
Observed MW: 495.3
Chemical Name or Material: 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
Assay Percent Range: __
Molecular Formula: C14H12ClN3O2.HCl
CAS: 1169562-71-3
Solubility: Soluble to 20mM in water
Formula Weight: Observed MW: 326.18
Chemical Name or Material:
8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
Assay Percent Range:
__
Molecular Formula:
C14H12ClN3O2.HCl
CAS:
1169562-71-3
Solubility:
Soluble to 20mM in water
Formula Weight:
Observed MW: 326.18