7114681
Tocris Bioscience™ Dacomitinib
Potent irreversible pan ErbB inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1110813-31-4
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Chemical Name or Material
(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
Assay Percent Range
>98%
Formula Weight
Observed MW: 469.94
CAS
1110813-31-4
Molecular Formula
C24H25ClFN5O2
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Description
- Potent irreversible pan ErbB inhibitor (IC50 values are 6.0, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively)
- Inhibits mutant and wild type forms of ErbB, including EGFR T780M, and shows activity in NSCLC cell lines sensitive and resistant to Iressa (Cat.No
- 3000)
- Inhibits tumor growth
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at 4°C
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Chemical Name or Material: (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
Assay Percent Range: >98%
Formula Weight: Observed MW: 469.94
CAS: 1110813-31-4
Molecular Formula: C24H25ClFN5O2
Chemical Name or Material:
(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide
Assay Percent Range:
>98%
Formula Weight:
Observed MW: 469.94
CAS:
1110813-31-4
Molecular Formula:
C24H25ClFN5O2
Chemical Name or Material: 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one
Assay Percent Range: >98%
Formula Weight: Observed MW: 328.67
CAS: 2036081-86-2
Molecular Formula: C14H8ClF3N2O2
Chemical Name or Material:
5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one
Assay Percent Range:
>98%
Formula Weight:
Observed MW: 328.67
CAS:
2036081-86-2
Molecular Formula:
C14H8ClF3N2O2
Chemical Name or Material: 1-[[2-[2-(4-Bromophenyl)ethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazole hydrochloride
Assay Percent Range: >98%
Formula Weight: Observed MW: 373.67
CAS: 939825-12-4
Molecular Formula: C15H17BrN2O2.HCl
Chemical Name or Material:
1-[[2-[2-(4-Bromophenyl)ethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazole hydrochloride
Assay Percent Range:
>98%
Formula Weight:
Observed MW: 373.67
CAS:
939825-12-4
Molecular Formula:
C15H17BrN2O2.HCl
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