7237113
Tocris Bioscience™ Neratinib
Potent HER2 receptor tyrosine kinase and EGFR kinase inhibitor
Manufacturer: Fischer Scientific
CAS Number: 698387-09-6
The price for this product is unavailable. Please request a quote
Chemical Name or Material
(2 E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
Target
EGF Receptor Inhibitors
Purity
0.98
CAS
698387-09-6
Molecular Formula
C30H29ClN6O3
Other Options
Related Products
Description
- Neratinib is a potent, irreversible inhibitor of HER-2/ErbB2 receptor tyrosine kinase and EGFR kinase (IC50 = 59 nM and 92 nM, respectively)
- Neratinib reduces receptor autophosphorylation and proliferation of EGFR-dependent cancer cells, blocks cell-cycle progression and inhibits HER-2 signaling pathways
- Neratinib suppresses proliferation of gefitinib -resistant non-small cell lung cancer cells expressing mutant EGFR
- Also inhibits MST1 (IC50 = 37.7 nM)
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: (2 E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
Target: EGF Receptor Inhibitors
Purity: 0.98
CAS: 698387-09-6
Molecular Formula: C30H29ClN6O3
Chemical Name or Material:
(2 E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
Target:
EGF Receptor Inhibitors
Purity:
0.98
CAS:
698387-09-6
Molecular Formula:
C30H29ClN6O3
Chemical Name or Material: N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine
Target: Cyclin-dependent Kinase Inhibitors
Purity: 0.98
CAS: 923596-52-5
Molecular Formula: C14H15N5
Chemical Name or Material:
N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine
Target:
Cyclin-dependent Kinase Inhibitors
Purity:
0.98
CAS:
923596-52-5
Molecular Formula:
C14H15N5
Chemical Name or Material: __
Target: __
Purity: __
CAS: __
Molecular Formula: __
Chemical Name or Material:
__
Target:
__
Purity:
__
CAS:
__
Molecular Formula:
__
Chemical Name or Material: __
Target: __
Purity: __
CAS: __
Molecular Formula: __
Chemical Name or Material:
__
Target:
__
Purity:
__
CAS:
__
Molecular Formula:
__