7116117
L Moses dihydrochloride
High affinity and selective PCAF bromodomain inhibitor
Manufacturer: Fischer Scientific
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Chemical Name or Material
(1S, 2S)-N1,N1-Dimethyl-N2-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine dihydrochloride
Assay Percent Range
>98%
Molecular Formula
C21H24N6.2HCl
Formula Weight
Observed MW: 433.38
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Description
- L Moses dihydrochloride is a high affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (Ki = 47 nM), which exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (Kd = 600 nM)
- L Moses exhibits >4500-fold selectivity for PCAF over BRD4
- The compound inhibits Tunicamycin (Cat
- No
- 3516) -induced neuronal cell death by reversing the transcriptional changes associated with Tunicamycin treatment
- L Moses exhibits metabolic stability in mouse and human liver microsomes and no observable cytotoxicity in peripheral blood mononuclear cells (PBMC).
SAFETY INFORMATION
- Recommended Storage : Desiccate at Room Temperature
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Chemical Name or Material: (1S, 2S)-N1,N1-Dimethyl-N2-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine dihydrochloride
Assay Percent Range: >98%
Molecular Formula: C21H24N6.2HCl
Formula Weight: Observed MW: 433.38
Chemical Name or Material:
(1S, 2S)-N1,N1-Dimethyl-N2-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine dihydrochloride
Assay Percent Range:
>98%
Molecular Formula:
C21H24N6.2HCl
Formula Weight:
Observed MW: 433.38
Chemical Name or Material: N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
Assay Percent Range: >98%
Molecular Formula: C25H31N3O5S2
Formula Weight: Observed MW: 517.66
Chemical Name or Material:
N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
Assay Percent Range:
>98%
Molecular Formula:
C25H31N3O5S2
Formula Weight:
Observed MW: 517.66
Chemical Name or Material: N-Methyl-5-[(phenylmethyl)thio]-1,3,4-thiazadiazol-2-amine
Assay Percent Range: >98%
Molecular Formula: C10H11N3S2
Formula Weight: Observed MW: 237.34
Chemical Name or Material:
N-Methyl-5-[(phenylmethyl)thio]-1,3,4-thiazadiazol-2-amine
Assay Percent Range:
>98%
Molecular Formula:
C10H11N3S2
Formula Weight:
Observed MW: 237.34
Chemical Name or Material: (5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione
Assay Percent Range: >98%
Molecular Formula: C21H21N3O2S
Formula Weight: Observed MW: 379.48
Chemical Name or Material:
(5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione
Assay Percent Range:
>98%
Molecular Formula:
C21H21N3O2S
Formula Weight:
Observed MW: 379.48