7121025
Tocris Bioscience™ TP 064
Potent and selective PRMT 4 inhibitor
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Chemical Name or Material
TP 064
Solubility
Soluble to 100mM in 1eq. HCl and to 100mM in DMSO
Formula Weight
458.6
Color
White
Purity
>98%
Synonym
N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
Molecular Formula
C28H34N4O2
Physical Form
Solid
Product Type
Bioactive Small Molecule
Related Products
Description
- TP 064 is a potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC50 values are <10 and 43 nM, respectively)
- Exhibits >100-fold selectivity over other histone methyltransferases and non-epigenetic targets
- Inhibits proliferation of certain multiple myeloma cell lines, arresting cells in G1 phase
- TP 064 can be used in vivo
- TP 064 inhibits the monocyte/macrophage-driven inflammation in ex vivo
- To request the negative control for TP 064, please fill out the TP 064N request form on the SGC website
- .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: TP 064
Solubility: Soluble to 100mM in 1eq. HCl and to 100mM in DMSO
Formula Weight: 458.6
Color: White
Purity: >98%
Synonym: N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
Molecular Formula: C28H34N4O2
Physical Form: Solid
Product Type: Bioactive Small Molecule
Chemical Name or Material:
TP 064
Solubility:
Soluble to 100mM in 1eq. HCl and to 100mM in DMSO
Formula Weight:
458.6
Color:
White
Purity:
>98%
Synonym:
N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
Molecular Formula:
C28H34N4O2
Physical Form:
Solid
Product Type:
Bioactive Small Molecule
Chemical Name or Material: FRAX 597
Solubility: Soluble to 20mM in DMSO
Formula Weight: 558.1
Color: Yellow
Purity: >98%
Synonym: 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one
Molecular Formula: C29H28ClN7OS
Physical Form: Solid
Product Type: Bioactive Small Molecule
Chemical Name or Material:
FRAX 597
Solubility:
Soluble to 20mM in DMSO
Formula Weight:
558.1
Color:
Yellow
Purity:
>98%
Synonym:
6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one
Molecular Formula:
C29H28ClN7OS
Physical Form:
Solid
Product Type:
Bioactive Small Molecule
Chemical Name or Material: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Solubility: __
Formula Weight: 479.4
Color: Orange
Purity: 98%
Synonym: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Molecular Formula: C25H22N60.2 HCl
Physical Form: Solid
Product Type: Bioactive Small Molecule
Chemical Name or Material:
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Solubility:
__
Formula Weight:
479.4
Color:
Orange
Purity:
98%
Synonym:
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Molecular Formula:
C25H22N60.2 HCl
Physical Form:
Solid
Product Type:
Bioactive Small Molecule
Chemical Name or Material: CZC 25146
Solubility: Soluble to 100mM in DMSO
Formula Weight: 488.54
Color: Pale-purple
Purity: >98%
Synonym: N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Molecular Formula: C22H25FN6O4S
Physical Form: Solid
Product Type: Bioactive Small Molecule
Chemical Name or Material:
CZC 25146
Solubility:
Soluble to 100mM in DMSO
Formula Weight:
488.54
Color:
Pale-purple
Purity:
>98%
Synonym:
N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Molecular Formula:
C22H25FN6O4S
Physical Form:
Solid
Product Type:
Bioactive Small Molecule