7161638
Tocris Bioscience™ JNJ 39758979 Dihydrochloride
High affinity and selective histamine H4 antagonist; orally bioavailable
Manufacturer: Fischer Scientific
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Chemical Name or Material
4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride
Molecular Formula
C11H19N5.2HCl
Formula Weight
294.22
Purity
98%
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Description
- High affinity and selective histamine H4 antagonist (Ki = 12.5 nM) Exhibits >80-fold selectivity for H4 over other histamine receptors and no significant activity at a range of other targets Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo Orally bioavailable
SAFETY INFORMATION
- Recommended Storage : Desiccate at Room Temperature
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Chemical Name or Material: 4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride
Molecular Formula: C11H19N5.2HCl
Formula Weight: 294.22
Purity: 98%
Chemical Name or Material:
4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride
Molecular Formula:
C11H19N5.2HCl
Formula Weight:
294.22
Purity:
98%
Chemical Name or Material: 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide
Molecular Formula: C16H19ClN2O3S
Formula Weight: 354.85
Purity: 98%
Chemical Name or Material:
2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide
Molecular Formula:
C16H19ClN2O3S
Formula Weight:
354.85
Purity:
98%
Chemical Name or Material: 3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol
Molecular Formula: C14H11N3OS
Formula Weight: 269.32
Purity: 98%
Chemical Name or Material:
3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol
Molecular Formula:
C14H11N3OS
Formula Weight:
269.32
Purity:
98%
Chemical Name or Material: 3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide
Molecular Formula: C20H16Br2N4O4
Formula Weight: 536.17
Purity: 98%
Chemical Name or Material:
3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide
Molecular Formula:
C20H16Br2N4O4
Formula Weight:
536.17
Purity:
98%