7182930

Tocris Bioscience™ OptoBI-1

Photoswitchable TRPC3/6/7 agonist

Manufacturer: Fischer Scientific

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Chemical Name or Material

1-[1-[4-[4-[(4-Butylphenyl)diazenyl]phenyl]butanoyl]piperidin-4-yl]-1,3-dihydro-2H-benzo[d]imidazol-2-one

Molecular Formula

C32H37N5O2

Purity

98%

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Description

  • Description OptoBI-1 is a photoswitchable TRPC3/6/7 agonist (EC50 for active cis -form ∽0.1 μM at TRPC3)
  • Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm
  • Returns to trans conformation in the dark after ∽ 50 minutes
  • No effect observed on TRPC4 or 5
  • Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis -state.

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Chemical Name or Material:
1-[1-[4-[4-[(4-Butylphenyl)diazenyl]phenyl]butanoyl]piperidin-4-yl]-1,3-dihydro-2H-benzo[d]imidazol-2-one

Molecular Formula:
C32H37N5O2

Purity:
98%

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Chemical Name or Material:
3-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methylbenzamide dihydrochloride

Molecular Formula:
C32H34F3N5O4.2HCl

Purity:
98%

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Chemical Name or Material:
5-[2-(2-(3-Fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-2-pyridinecarboxamide

Molecular Formula:
C19H19FN2O2

Purity:
98%

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Chemical Name or Material:
5-Amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

Molecular Formula:
C17H17FN4O2S

Purity:
98%