7250155
Tocris Bioscience™ Masitinib
Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor
Manufacturer: Fischer Scientific
CAS Number: 790299-79-5
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Chemical Name or Material
4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
Target
CD117/c-kit
Purity
0.98
CAS
790299-79-5
Molecular Formula
C28H30N6OS
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ Masitinib | Fischer Scientific | ₹ 12,703.95 | |
| | Tocris Bioscience™ Masitinib | Fischer Scientific | ₹ 53,694.03 | |
 | Medchemexpress LLC HY-10209 50mg , Masitinib CAS:790299-79-5 Purity:>98% | Medchemexpress LLC | ₹ 10,690.72 | |
 | Selleck Chemical LLC Masitinib (AB1010) 25mg 790299-79-5 | Selleck Chemical LLC | ₹ 37,988.64 | |
 | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide | Aaron Chemicals LLC | ₹ 4,534.68 - ₹ 11,208.36 | |
 | 790299-79-5 | N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide | A2B Chem | ₹ 1,112.28 - ₹ 36,277.44 |
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Description
- Masitinib is a potent inhibitor of the tyrosine kinase receptor colony-stimulating factor 1R (CSF-1R) (IC50 = 90 nM)
- It is also an NLRP3 inflammasome activator
- Masitinib additionally inhibits the proteolytic activity of SARS-CoV-2 main protease (Mpro) and blocks viral replication, as well as acting as a PDGFRα/β inhibitor
- In vivo , Masitinib ameliorates cognitive impairment in transgenic mice model of Alzheimer's disease, and slows disease progression in a rat model of amyotrophic lateral sclerosis (ALS)
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
Target: CD117/c-kit
Purity: 0.98
CAS: 790299-79-5
Molecular Formula: C28H30N6OS
Chemical Name or Material:
4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
Target:
CD117/c-kit
Purity:
0.98
CAS:
790299-79-5
Molecular Formula:
C28H30N6OS
Chemical Name or Material: 8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
Target: DNA, RNA and Protein Synthesis Compounds
Purity: 0.98
CAS: 1258453-75-6
Molecular Formula: C16H10ClF3N2O
Chemical Name or Material:
8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
Target:
DNA, RNA and Protein Synthesis Compounds
Purity:
0.98
CAS:
1258453-75-6
Molecular Formula:
C16H10ClF3N2O
Chemical Name or Material: 1-[4-[5-(4-Fluoro-3,5-dimethoxyphenyl)-4-methyl-3-pyridinyl]phenyl]piperazine dihydrochloride
Target: ALK/CD246
Purity: 0.98
CAS: __
Molecular Formula: C24H26FN3O20.2 HCl
Chemical Name or Material:
1-[4-[5-(4-Fluoro-3,5-dimethoxyphenyl)-4-methyl-3-pyridinyl]phenyl]piperazine dihydrochloride
Target:
ALK/CD246
Purity:
0.98
CAS:
__
Molecular Formula:
C24H26FN3O20.2 HCl
Chemical Name or Material: 4-Fluoro-3-[[[5-(1-methyl-1 H-pyrazol-3-yl)-3-pyridinyl]methyl]amino]-N-[3-(trifluoromethoxy)phenyl]benzamide
Target: DDR1/DDR2
Purity: 0.98
CAS: 2442597-56-8
Molecular Formula: C24H19F4N5O2
Chemical Name or Material:
4-Fluoro-3-[[[5-(1-methyl-1 H-pyrazol-3-yl)-3-pyridinyl]methyl]amino]-N-[3-(trifluoromethoxy)phenyl]benzamide
Target:
DDR1/DDR2
Purity:
0.98
CAS:
2442597-56-8
Molecular Formula:
C24H19F4N5O2