Home Products Protein Analysis Reagents Bioactive Small Molecules 7182958
7182958

Tocris Bioscience™ TL 0259

Selective and highly potent Fgr and Lyn kinase inhibitor; orally bioavailable

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Chemical Name or Material

3-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methylbenzamide dihydrochloride

Molecular Formula

C32H34F3N5O4.2HCl

Purity

98%

Related Products

Img

Fischer Scientific

7146026

Potent MAP4K2 (GCK) inhibitor...

Img

Tocris Bioscience™

54-295-R

--

Img

Fischer Scientific

7161630

Negative control for GSK 6853...

Img

Fischer Scientific

7139255

High affinity NK1 receptor antagoni...

Img

Fischer Scientific

7250158

Potent and selective ALK2 inhibitor...

Img

Fischer Scientific

7199105

Highly potent and selective ROCK 2 ...

Img

Fischer Scientific

7180144

Potent and selective EZH2 inhibitor...

Img

Fischer Scientific

77-541-0

--

Description

  • TL 0259 is a selective and highly potent Fgr and Lyn inhibitor (IC50 values are 0.03 and 0.1 nM, respectively)
  • Exhibits selectivity for Fgr and Lyn over other Src family kinases and other nonreceptor and receptor tyrosine kinases
  • Suppresses proliferation of acute myelogenous leukemia (AML) cell lines in vitro
  • Eliminates leukemic cells from spleen and bone of mice bearing AML xenografts
  • Orally bioavailable.

Compare Similar Items

Show Difference

Img

Fischer Scientific

7182958

Selective and highly potent Fgr and...

Chemical Name or Material:
3-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methylbenzamide dihydrochloride
Molecular Formula:
C32H34F3N5O4.2HCl
Purity:
98%

Img

Fischer Scientific

7182960

Potent mGlu5 positive allosteric mo...

Chemical Name or Material:
5-[2-(2-(3-Fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-2-pyridinecarboxamide
Molecular Formula:
C19H19FN2O2
Purity:
98%

Img

Fischer Scientific

7182961

Potent and selective positive allos...

Chemical Name or Material:
5-Amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
Molecular Formula:
C17H17FN4O2S
Purity:
98%

Img

Fischer Scientific

7182976

Multi-piece Safety Pack Graduated C...

Chemical Name or Material:
__
Molecular Formula:
__
Purity:
__