7223003
Tocris Bioscience™ TCH-165
Enhancer of 20S proteasome assembly and 20S-mediated protein degradation
Manufacturer: Fischer Scientific
CAS Number: 1446350-60-2
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Chemical Name or Material
Ethyl (4 R,5 R)-rel-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1 H-imidazole-4-carboxylate
Target
Proteasome Modulators
Purity
0.98
CAS
1446350-60-2
Molecular Formula
C39H37N3O3
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ TCH-165 | Fischer Scientific | ₹ 22,887.30 | |
| | Tocris Bioscience™ TCH-165 | Fischer Scientific | ₹ 95,998.32 |
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Description
- TCH-165 is an enhancer of 20S proteasome assembly
- TCH-165 regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation
- TCH-165 enhances the proteolytic activity of the 20S proteasome by increasing substrate accessibility to the 20S catalytic chamber through 20S gate opening
- TCH-165 enhances 20S-mediated degradation of IDPs, α-syn, and tau in vitro , and does not induce the degradation of structured proteins such as GAPDH
- TCH-165 enhances c-MYC degradation by the 20S proteasome, which reduces c-MYC levels in vivo , and is effective in bortezomib (Cat
- No
- 7282) resistant cells
- TCH-165 down-regulates c-MYC target genes and inhibits cancer cell proliferation and tumor growth in vivo .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: Ethyl (4 R,5 R)-rel-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1 H-imidazole-4-carboxylate
Target: Proteasome Modulators
Purity: 0.98
CAS: 1446350-60-2
Molecular Formula: C39H37N3O3
Chemical Name or Material:
Ethyl (4 R,5 R)-rel-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1 H-imidazole-4-carboxylate
Target:
Proteasome Modulators
Purity:
0.98
CAS:
1446350-60-2
Molecular Formula:
C39H37N3O3
Chemical Name or Material: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
Target: VEGF Receptor Inhibitors
Purity: 0.98
CAS: 443913-73-3
Molecular Formula: C22H24BrFN4O2
Chemical Name or Material:
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine
Target:
VEGF Receptor Inhibitors
Purity:
0.98
CAS:
443913-73-3
Molecular Formula:
C22H24BrFN4O2
Chemical Name or Material: 6,7-Dihydro-N-(5-methyl-2-thiazolyl)-5 H-indeno[5,6-b]furan-3-acetamide
Target: Molecular Glues
Purity: 0.98
CAS: 790245-61-3
Molecular Formula: C17H16N2O2S
Chemical Name or Material:
6,7-Dihydro-N-(5-methyl-2-thiazolyl)-5 H-indeno[5,6-b]furan-3-acetamide
Target:
Molecular Glues
Purity:
0.98
CAS:
790245-61-3
Molecular Formula:
C17H16N2O2S
Chemical Name or Material: 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2 H)-phthalazinone
Target: Poly(ADP-ribose) Polymerase Inhibitors
Purity: 0.98
CAS: 763113-22-0
Molecular Formula: C24H23FN4O3
Chemical Name or Material:
4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2 H)-phthalazinone
Target:
Poly(ADP-ribose) Polymerase Inhibitors
Purity:
0.98
CAS:
763113-22-0
Molecular Formula:
C24H23FN4O3