7235737
Tocris™ AGI 5198
Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)
Manufacturer: Fischer Scientific
CAS Number: 1355326-35-0
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Chemical Name or Material
N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1 H-Imidazole-1-acetamide
Target
Dehydrogenase Inhibitors
Purity
0.98
CAS
1355326-35-0
Molecular Formula
C27H31FN4O2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris™ AGI 5198 | Fischer Scientific | ₹ 51,510.54 | |
| | Tocris™ AGI 5198 | Fischer Scientific | ₹ 12,306.95 | |
| | Thermo Scientific™ AGI-5198, 95% | Thermo Scientific™ | ₹ 43,122.24 | |
 | Medchemexpress LLC HY-18082 100mg , AGI-5198 IDH-C35 CAS:1355326-35-0 Purity:98% | Medchemexpress LLC | ₹ 14,823.27 | |
 | eMolecules Medchem Express / AGI-5198 / 10mg / 446268882 / HY-18082 / / 1355326-35-0 / MFCD24848688 / 462.569 / C27H31FN4O2 | eMolecules | ₹ 8,312.15 | |
 | 1355326-35-0 | Agi-5198 | A2B Chem | ₹ 2,652.36 - ₹ 15,400.80 |
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Description
- AGI 5198 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1; IC50 = 70 nM)
- Selective for mIDH1 over wild-type IDH1 and IDH2
- Inhibits production of oncometabolite D-2 hydroxyglutarate
- Attenuates growth of glioma cells containing mIDH1, but not wild-type IDH1, in vitro and in vivo
- Also inhibits growth of fibrosarcoma and chondrosarcoma cells bearing mIDH1.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1 H-Imidazole-1-acetamide
Target: Dehydrogenase Inhibitors
Purity: 0.98
CAS: 1355326-35-0
Molecular Formula: C27H31FN4O2
Chemical Name or Material:
N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1 H-Imidazole-1-acetamide
Target:
Dehydrogenase Inhibitors
Purity:
0.98
CAS:
1355326-35-0
Molecular Formula:
C27H31FN4O2
Chemical Name or Material: N1-(1-Propyl-1 H-benzimidazol-2-yl)-1,3-benzenedicarboxamide
Target: Other Kinase Inhibitors
Purity: 0.98
CAS: 1111556-37-6
Molecular Formula: C18H18N4O2
Chemical Name or Material:
N1-(1-Propyl-1 H-benzimidazol-2-yl)-1,3-benzenedicarboxamide
Target:
Other Kinase Inhibitors
Purity:
0.98
CAS:
1111556-37-6
Molecular Formula:
C18H18N4O2
Chemical Name or Material: N-[(5-Methyl-3-isoxazolyl)carbonyl]-L-alanyl-L-valyl-N-[(1 S,2 E)-4-oxo-1-[[(3 S)-2-oxo-3-pyrrolidinyl]methyl]-4-(phenylmethoxy)-2-buten-1-yl]-L-leucinamide
Target: Additional Synthetic Protease Inhibitors
Purity: 0.98
CAS: 884650-98-0
Molecular Formula: C35H48N6O8
Chemical Name or Material:
N-[(5-Methyl-3-isoxazolyl)carbonyl]-L-alanyl-L-valyl-N-[(1 S,2 E)-4-oxo-1-[[(3 S)-2-oxo-3-pyrrolidinyl]methyl]-4-(phenylmethoxy)-2-buten-1-yl]-L-leucinamide
Target:
Additional Synthetic Protease Inhibitors
Purity:
0.98
CAS:
884650-98-0
Molecular Formula:
C35H48N6O8
Chemical Name or Material: N'-(4-Fluoro-5-methyl-[1,1 '-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide
Target: Histone Acetyltransferase Inhibitors
Purity: 0.98
CAS: 2229025-70-9
Molecular Formula: C20H17FN2O4S
Chemical Name or Material:
N'-(4-Fluoro-5-methyl-[1,1 '-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide
Target:
Histone Acetyltransferase Inhibitors
Purity:
0.98
CAS:
2229025-70-9
Molecular Formula:
C20H17FN2O4S