7199112
Tocris™ RIPGBM
RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant
Manufacturer: Fischer Scientific
CAS Number: 355406-76-7
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Chemical Name or Material
N-[1,4-Dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]acetamide
Target
RIP Kinase Inhibitors
Purity
98%
CAS
355406-76-7
Molecular Formula
C26H21FN2O3
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris™ RIPGBM | Fischer Scientific | ₹ 22,919.28 | |
| | Tocris™ RIPGBM | Fischer Scientific | ₹ 96,529.40 | |
 | eMolecules Medchem Express / RIPGBM / 5mg / 536983973 / HY-122910 / / 355406-76-7 / MFCD05670032 / 428.463 / C26H21FN2O3 | eMolecules | ₹ 8,646.35 |
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Description
- RIPK2 modulator, pro-drug of cRIPGM
- cRIPGM binds RIPK2 (apparent Kd = 2.3 μM)
- Selectively induces apoptosis in glioblastoma multiforme cancer stem cell lines (EC50 is <500 nM)
- Five-fold selective for CSCs compared with control cell types
- Reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex
- Inhibits tumor formation and growth in vivo
- Orally bioavailable and brain penetrant.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: N-[1,4-Dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]acetamide
Target: RIP Kinase Inhibitors
Purity: 98%
CAS: 355406-76-7
Molecular Formula: C26H21FN2O3
Chemical Name or Material:
N-[1,4-Dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]acetamide
Target:
RIP Kinase Inhibitors
Purity:
98%
CAS:
355406-76-7
Molecular Formula:
C26H21FN2O3
Chemical Name or Material: __
Target: STING Antagonists
Purity: 97%
CAS: 314054-00-7
Molecular Formula: C11H7IN2O4
Chemical Name or Material:
__
Target:
STING Antagonists
Purity:
97%
CAS:
314054-00-7
Molecular Formula:
C11H7IN2O4
Chemical Name or Material: Ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate
Target: Toll-like Receptor Antagonists
Purity: 97%
CAS: 313254-94-3
Molecular Formula: C15H14O7
Chemical Name or Material:
Ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate
Target:
Toll-like Receptor Antagonists
Purity:
97%
CAS:
313254-94-3
Molecular Formula:
C15H14O7
Chemical Name or Material: 4-[2,5-Dihydro-2,3-dimethyl-4-(1-methylethyl)-5-oxo-1 H-pyrazol-1-yl]-N-(2-phenoxyethyl)benzenesulfonamide
Target: Ras GTPase Inhibitors
Purity: 98%
CAS: 695207-56-8
Molecular Formula: C22H27N3O4S
Chemical Name or Material:
4-[2,5-Dihydro-2,3-dimethyl-4-(1-methylethyl)-5-oxo-1 H-pyrazol-1-yl]-N-(2-phenoxyethyl)benzenesulfonamide
Target:
Ras GTPase Inhibitors
Purity:
98%
CAS:
695207-56-8
Molecular Formula:
C22H27N3O4S